Cohort profile: the Spanish Early-onset Colorectal Cancer (SECOC) cohort: a multicentre cohort study on the molecular basis of colorectal cancer among young individuals in Spain. Issue 12 (30th December 2021)

• Record Type: Journal Article
• Authors: Perea, Jose; Marti, Marc; Espin, Eloy; Hernandez-Villafranca, Sergio; Orihuela, Pilar; Vidal Tocino, Rosario; Alcazar, Jose Antonio; Vivas, Alfredo; Narvaez, Cristina; Prieto, Isabel; Asensio, Luis; López Rojo, Irene; Encinas Garcia, Sara; Hurtado, Elena; Jiménez, Luis M; Jiménez, Fernando; Cavero, Adriana; Alvaro, Edurne; Fuenmayor, Maria Luisa; Jiménez Toscano, Marta; Iglesias Comas, Mar; Balaguer, Francesc; Daca, Maria; Ballestero, Araceli; Die Trill, Javier; Sanz, Gonzalo; Sanz López, Rodrigo; Melone, Sirio; Rueda, Jose A; Brandariz, Lorena; Valverde, Ignacio; Arredondo, Jorge; Pastor, Carlos; Garcia-Olmo, Damian; Malats, Nuria; Urioste, Miguel; Gonzalez-Sarmiento, Rogelio; Spinelli, Antonino; Holowatyj, Andreana N;
• Other Names: author non-byline.; Santos Cristina author non-byline.; Villacampa Mercedes Martínez author non-byline.; Moreno Víctor author non-byline.; Ruffinelli Jose Carlos author non-byline.; Inglada-Pérez Lucía author non-byline.; Sueda Orgaz José A author non-byline.; Megías Víctor Castellano author non-byline.; Olmedillas-López Susana author non-byline.; Portugal Vicente author non-byline.; Domenech María Arriba author non-byline.; Gómez Isabel Peligros author non-byline.; Valcárcel Cristina Rey author non-byline.; Ortúzar Jaime Zorrilla author non-byline.; Ocaña Teresa author non-byline.; Cuatrecasas Miriam author non-byline.; Carballal Sabela author non-byline.; Moreira Leticia author non-byline.; Moreno Lorena author non-byline.; Pellisé María author non-byline.; Sánchez Ariadna author non-byline.; Molina Ana Ramírez de author non-byline.; Colmenarejo Gonzalo author non-byline.; Espinosa-Salinas Isabel author non-byline.; Fernández Lara author non-byline.; Cedrón Marta Gómez de author non-byline.; Corchete Luis author non-byline.; García Juan L author non-byline.; Vallés Paula García author non-byline.; Hernández Ana B author non-byline.; Martel Abel J author non-byline.; Pérez Jéssica author non-byline.; Burdaspal Ana author non-byline.; Forero Alejandro author non-byline.; Rubio Inés author non-byline.; Pastor Enrique author non-byline.; Fernández Jesús author non-byline.; Villafañe Amaya author non-byline.; Alonso Oscar author non-byline.; Encinas Sara author non-byline.; Teijo Ana author non-byline.; Fons Jorge Baixauli author non-byline.; Paredes Lucia Ceniceros author non-byline.; Rodriguez Javier author non-byline.; Justicia Carlos Sánchez author non-byline.; Dziakova Jana author non-byline.; Marín Sara Picazo author non-byline.; Solís María Suárez author non-byline.; García Jacinto author non-byline.; Estudillo Lidia author non-byline.; Pérez-Pérez Julián author non-byline.; Marinello Franco author non-byline.; Kraft Miquel author non-byline.; Landolfi Stefania author non-byline.; Salces Inmaculada author non-byline.; Tapial Sandra author non-byline.;
• Is Part Of: BMJ open. Volume 11:Issue 12(2021)
• Publication Date: 2021-12-30
• Subjects: cancer genetics -- gastrointestinal tumours -- colorectal surgery; Medicine -- Research -- Periodicals; 610.72
• DOI: 10.1136/bmjopen-2021-055409
• Languages: English
• ISSNs: 2044-6055

Abstract

Abstract : Purpose: The Spanish Early-onset Colorectal Cancer (SECOC) study is a multicentre prospective cohort established in Spain to investigate the molecular basis of early-onset colorectal cancer (EOCRC), including metabolic alterations. Participants: 220 patients with EOCRC have been enrolled since January 2019 through 18 centres across Spain. Individual-level data were collected by questionnaire, including lifestyle and other colorectal cancer-related factors. Medical record review was performed to capture clinical, histopathological and familial cancer history data. Biospecimen collection (blood, stool, tissue) at diagnosis and at various time points across treatment, as applicable, is also completed. Findings to date: Participants had a median age of 44 years (range 14–49), and the majority are men (60%), with individuals age 40–49 years at EOCRC diagnosis being over-represented. Forty-three per cent of participants were diagnosed with a tumour in the rectosigmoid junction/rectum. Nearly two-thirds of EOCRC cases (64%) were diagnosed with advanced stage (III–IV) disease, and 28% of cases had no reported familial history of cancer. Future plans: We are actively recruiting and observing participants; we plan to administer follow-up questionnaires and perform additional biospecimen collection. This prospective cohort offers a unique, rich resource for research on EOCRC aetiologies and will contribute to larger international efforts to disentangle the rising disease burden.