IgG4 disease as a differential diagnosis of head and neck squamous cell carcinoma. (17th March 2021)

• Record Type: Journal Article
• Authors: Swansbury, Andrew; Pilkington, Richard J. J.; Kennedy, Matthew; Adams, James R.
• Is Part Of: Oral surgery. Volume 15:Number 1(2022)
• Page Start: 88
• Page End: 92
• Publication Date: 2021-03-17
• Subjects: IgG4 -- differential diagnosis -- carcinoma; Mouth -- Surgery -- Periodicals; 617.522059
• DOI: 10.1111/ors.12605
• Languages: English
• ISSNs: 1752-2471

Abstract

Abstract: Aim: To highlight the need to include IgG4 disease in the differential diagnosis of head and neck squamous cell carcinoma (SCC). Method: We will present two cases which recently presented to the Maxillofacial Department at the RVI hospital, Newcastle, UK. One had a large palatal ulceration and one had a soft tissue mass on the orbital floor with extensions into the maxillary antrum. Results: Both cases had clinical and radiographic features indicative of SCC, however, following biopsy a definitive diagnosis of IgG4 disease was made. The patients were treated successfully medically via MDT (Multidisciplinary Team) with rheumatology. This involved the use of immunosuppressants including Prednisolone and Rituximab. Conclusions: Treatment for head/neck SCC typically involves large resections with significant impacts upon a patient's quality of life. Therefore, it is important that alternative diagnosis is considered and excluded. We hope these cases show that IgG4 disease should be on this list.