Insight of oral vaccines as an alternative approach to health and disease management: An innovative intuition and challenges. Issue 2 (18th November 2021)

• Record Type: Journal Article
• Authors: Debnath, Nabendu; Thakur, Mony; Khushboo, ; Negi, Neelam P.; Gautam, Vibhav; Kumar Yadav, Ashok; Kumar, Deepak
• Is Part Of: Biotechnology and bioengineering. Volume 119:Issue 2(2022)
• Page Start: 327
• Page End: 346
• Publication Date: 2021-11-18
• Subjects: edible vaccine -- genetically modified plants -- immune response -- mucosal immunity -- transgenic bacteria; Biotechnology -- Periodicals; Bioengineering -- Periodicals; 660.6
• DOI: 10.1002/bit.27987
• Languages: English
• ISSNs: 0006-3592

Abstract

Abstract: Vaccination is the most suitable and persuasive healthcare program for the prohibition of various deadly diseases. However, the higher production cost and purification strategies are out of reach for the developing nations. In this scenario, development of edible vaccine turns out to be the most promising alternative for remodeling the pharmaceutical industry with reduced production and purification costs. Generally, oral route of vaccination is mostly preferred due to its safety, compliance, low manufacturing cost and most importantly the ability to induce immunity in both systemic and mucosal sites. Genetically modified microorganisms and plants could efficiently be used as vehicles for edible vaccines. Edible vaccines are supposed to reduce the risk associated with traditional vaccines. Currently, oral vaccines are available in the market for several viral and bacterial diseases like cholera, hepatitis B, malaria, rabies etc. Herein, the review focuses on the breakthrough events in the area of edible vaccines associated with dietary microbes and plants for better control over diseases. Abstract : Bio‐engineered bacteria and plants as an oral vaccine directly stimulates mucosal immune system along with systemic immunity. Thereby, providing a strong protective action against several diseases. Several bacteria and plants showcased in this review demonstrates the most promising characteristics which in the future can be used as vaccine vehicle. This approach of vaccinations, so called "Therapeutic Food", can initiate an era with full control over infectious diseases.