Stimuli‐Responsive DNA Origami Nanodevices and Their Biological Applications. (15th November 2021)

• Record Type: Journal Article
• Authors: Pitikultham, Piyawat; Wang, Zhaoran; Wang, Yiming; Shang, Yingxu; Jiang, Qiao; Ding, Baoquan
• Is Part Of: ChemMedChem. Volume 17:Number 1(2022)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2021-11-15
• Subjects: DNA origami -- stimuli-responsive -- DNA nanodevices -- biological application; Pharmaceutical chemistry -- Periodicals; 615.19005
• DOI: 10.1002/cmdc.202100635
• Languages: English
• ISSNs: 1860-7179

Abstract

Abstract: DNA origami nanotechnology has provided predictable static nanoarchitectures and dynamic nanodevices with rationally designed geometries, precise spatial addressability, and marked biocompatibility. Multiple functional elements, such as peptides, aptamers, nanoparticles, fluorescence probes, and proteins, etc. can be easily integrated into DNA origami templates with nanoscale precision, leading to a variety of promising applications. Triggered by chemical/physical stimuli, dynamic DNA origami nanodevices can switch between defined conformations or translocate autonomously, providing powerful tools for intelligent biosensing and drug delivery. In this minireview, we summarize the recent progress of dynamic DNA origami nanodevices with desired reconfigurability and feasibility to perform multiple biological tasks. We introduce varieties of DNA nanodevices that can be controlled by different molecular triggers and external stimuli. Subsequently, we highlight the recent advances in employing DNA nanodevices as biosensors and drug delivery vehicles. At last, future possibilities and perspectives are also discussed. Abstract : A variety of dynamic DNA origami nanodevices driven by different chemical/physical stimuli have been reported. Integrating multiple responsive and biofunctional components, dynamic DNA origami nanodevices are exhibiting great potential in performing a plethora of biological applications, such as smart sensing, drug delivery and cancer therapy. Recent progress and perspectives in the biological applications of dynamic DNA nanodevices has been summarized.