Head‐to‐Head Comparison of Selected Extra‐ and Intracellular CO‐Releasing Molecules on Their CO‐Releasing and Anti‐Inflammatory Properties. (26th October 2021)

• Record Type: Journal Article
• Authors: Li, Yingchun; Hemmersbach, Lars; Krause, Bernhard; Sitnikov, Nikolay; Schlundt née Göderz, Anna; Pastene Maldonado, Diego O.; Schmalz, Hans‐Günther; Yard, Benito
• Is Part Of: Chembiochem. Volume 23:Number 1(2022)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2021-10-26
• Subjects: anti-inflammatory agents -- heme oxygenases -- iron carbonyl complexes -- prodrugs -- carbon monoxide; Biochemistry -- Periodicals; Molecular biology -- Periodicals; Pharmaceutical chemistry -- Periodicals; 572
• DOI: 10.1002/cbic.202100452
• Languages: English
• ISSNs: 1439-4227

Abstract

Abstract: Over the past decade, a variety of carbon monoxide releasing molecules (CORMs) have been developed and tested. Some CORMs spontaneously release CO once in solution, while others require a trigger mechanism to release the bound CO from its molecular complex. The modulation of biological systems by CORMs depends largely on the spatiotemporal release of CO, which likely differs among the different types of CORMs. In spontaneously releasing CORMs, CO is released extracellularly and crosses the cell membrane to interact with intracellular targets. Other CORMs can directly release CO intracellularly, which may be a more efficient method to modulate biological systems. In the present study, we compared the efficacy of extracellular and intracellular CO‐releasing CORMs that either release CO spontaneously or require an enzymatic trigger. The efficacy of such CORMs to modulate HO‐1 and VCAM‐1 expression in TNF‐α‐stimulated human umbilical vein endothelial cells (HUVEC) was evaluated. Abstract : The beneficial anti‐inflammatory effects of carbon monoxide were studied using differently triggered CO‐releasing molecules (CORMs). In particular, some acyloxy‐Fe(CO)3 complexes acting as enzyme‐triggered CORMs showed pronounced cellular effects regardless of whether CO release was intra‐ or extracellular.