Adhesive Capable of Underwater Adhesion and Wound Hemostasis Prepared Based on Solvent Exchange. Issue 1 (12th September 2021)

• Record Type: Journal Article
• Authors: Song, Qiantao; Chen, Yining; Huang, Yanping; Dan, Weihua; Wang, Meng; Dan, Nianhua
• Is Part Of: Advanced materials technologies. Volume 7:Issue 1(2022)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2021-09-12
• Subjects: antibacterial -- dopamine -- solvent exchange -- underwater adhesion -- wound hemostasis; Materials science -- Periodicals; Technological innovations -- Periodicals; Materials science; Technological innovations; Periodicals; 620.1105
• DOI: 10.1002/admt.202100852
• Languages: English
• ISSNs: 2365-709X

Abstract

Abstract: Whether used for underwater adhesion or wound hemostasis, adhesives are required to have strong wet adhesion. However, traditional adhesives are difficult to break through the blockade of the hydration interface, so they cannot achieve strong underwater adhesion, and their biological toxicities are also greater, not suitable for wound hemostasis. In this work, small molecule polyethylene glycol diacrylate (PEGDA‐200) and dopamine (DA) with good biocompatibility are used as raw materials to synthesize a long chain polymer (PDDA) with hydrophobic backbone and hydrophilic group through the Michael addition reaction. Based on the hydrogen bond interaction between PDDA and silicotungstic acid (SiW) and the solvent exchange between dimethyl sulfoxide and water, the two are successfully caused to agglomerate and form a viscous aggregate (PDDA‐SiW). PDDA‐SiW not only has strong underwater adhesion to various substrates, but also has strong adhesion and readhesion to fresh pigskins. In addition, PDDA‐SiW also has very low hemolysis and cytotoxicity and strong antibacterial properties, and it is a very good underwater adhesion and wound hemostatic material. Abstract : The long‐chain polymer (PDDA) is prepared by the Michael addition reaction of polyethylene glycol diacrylate and dopamine. An excellent underwater adhesive is prepared using the solvent exchange between water and dimethyl sulfoxide and the hydrogen bond interaction between PPDA and silicotungstic acid. It not only has strong adhesion ability, but also has great application potential in wound hemostasis.