Bacterial infection in dogs with aspiration pneumonia at 2 tertiary referral practices. (9th November 2021)

• Record Type: Journal Article
• Authors: Howard, Jennifer; Reinero, Carol R.; Almond, Greg; Vientos‐Plotts, Aida; Cohn, Leah A.; Grobman, Megan
• Is Part Of: Journal of veterinary internal medicine. Volume 35:Number 6(2021)
• Page Start: 2763
• Page End: 2771
• Publication Date: 2021-11-09
• Subjects: antimicrobial -- bacterial culture -- bronchoalveolar lavage fluid -- pneumonitis -- thoracic radiography; Veterinary medicine -- Periodicals; 636.0896
• DOI: 10.1111/jvim.16310
• Languages: English
• ISSNs: 0891-6640

Abstract

Abstract: Background: In dogs, antimicrobial drugs are widely prescribed for aspiration pneumonia (AP) despite poor documentation of bacterial infection in AP (b‐AP) using bronchoalveolar lavage fluid (BALF) analysis. Interpretating discordant cytology and culture results is challenging, contributing to lack of a criterion standard, and highlighting differences between veterinary and human medical criteria for b‐AP. Objectives: Determine how many dogs with AP had BALF collection and differences in diagnosis of b‐AP using veterinary vs human medical criteria. Report findings of noninvasive markers (e.g. fever, band neutrophilia, radiographic severity score) in dogs with and without b‐AP. Animals: Retrospective cohort study of client‐owned dogs (n = 429) with AP at 2 university veterinary hospitals. Twenty‐four dogs met enrollment criteria. Methods: Inclusion criteria were radiographic diagnosis of AP, ≥1 risk factor, CBC findings, and BALF cytology and culture results. Veterinary medical b‐AP criteria were cytology findings compatible with sepsis with or without positive culture, or cytology findings not consistent with sepsis and positive culture (≥1.7 × 10 3 cfu/mL). Human medical b‐AP criteria required culture with ≥10 4 cfu/mL or > 7% cells with intracellular bacteria on cytology. Results: Only 24/429 dogs met all enrollment criteria; 379/429 dogs lacked BALF collection. Diagnosis of b‐AP differed using veterinary (79%) vs human (29%) medical criteria. Fever, band neutrophils and high radiographic scores were noted in dogs with and without b‐AP. Conclusions and Clinical Importance: Lack of routine BALF collection hampers definitive recognition of bacterial infection in AP. Differences in dogs meeting veterinary vs human medical definitions for b‐AP and usefulness of noninvasive markers warrant further study to improve understanding of the role of bacteria in AP.