Biotransformation of sesquiterpenoids: a recent insight. Issue 2 (10th January 2022)

• Record Type: Journal Article
• Authors: Aminudin, Nurul Iman; Ridzuan, Munirah; Susanti, Deny; Zainal Abidin, Zaima Azira
• Is Part Of: Journal of Asian natural products research. Volume 24:Issue 2(2022)
• Page Start: 103
• Page End: 145
• Publication Date: 2022-01-10
• Subjects: Biotransformation -- sesquiterpenoids -- biocatalysts -- drug-design; Materia medica -- Asia -- Periodicals; Pharmacognosy -- Asia -- Periodicals; Medicinal plants -- Asia -- Periodicals; Medicine, Oriental -- Asia -- Periodicals; 615.321095
• DOI: 10.1080/10286020.2021.1906657
• Languages: English
• ISSNs: 1028-6020

Abstract

Abstract: Sesquiterpenoids have been identified as natural compounds showing remarkable biological activities found in medicinal plants. There is great interest in developing methods to obtain sesquiterpenoids derivatives and biotransformation is one of the alternative methods for structural modification of complex sesquiterpenes structures. Biotransformation is a great drug design tool offering high selectivity and green method. The present review describes a comprehensive summary of biotransformation products of sesquiterpenoids and its structural modification utilizing a variety of biocatalysts including microorganisms, plant tissue culture and enzymes. This review covers recent literatures from 2007 until 2020 and highlights the experimental conditions for each biotransformation process. Graphical Abstract: UF0001