Renoprotective activity of a new amide and a new hydroxycinnamic acid derivative from the fresh roots of Rehmannia glutinosa. Issue 2 (10th January 2022)

• Record Type: Journal Article
• Authors: Liu, Yan-Ling; Cao, Yan-Gang; Kan, Yu-Xuan; Ren, Ying-Jie; Wang, Meng-Na; Fan, Xi-Ling; Zheng, Xiao-Ke; Feng, Wei-Sheng
• Is Part Of: Journal of Asian natural products research. Volume 24:Issue 2(2022)
• Page Start: 163
• Page End: 169
• Publication Date: 2022-01-10
• Subjects: Scrophulariaceae -- fresh Rehmannia glutinosa -- amide -- hydroxycinnamic acid derivative -- NRK-52e cells; Materia medica -- Asia -- Periodicals; Pharmacognosy -- Asia -- Periodicals; Medicinal plants -- Asia -- Periodicals; Medicine, Oriental -- Asia -- Periodicals; 615.321095
• DOI: 10.1080/10286020.2021.1912027
• Languages: English
• ISSNs: 1028-6020

Abstract

Abstract: A new amide, named rehmagluamide (1 ), and a new hydroxycinnamic acid derivative, named nepetoidin F (2 ), together with six known compounds, 2′- O -methyluridine (3 ), puroglutamic acid (4 ), biliverdic acid (5 ), peterolactam (6 ), nicotinic acid (7 ), nicotinamide (8 ), were isolated from the fresh roots of Rehmannia glutinosa . All the structures of compounds were identified by the interpretation of their spectroscopic data and comparison with those reported in the literatures. The protective effects of compounds 1–7 on normal rat kidney tubule epithelioid (NRK-52e) cells injury induced by LPS were investigated. The results indicated that compounds 1, 2, and 7 exhibited protective effects against LPS-induced NRK 52e cells injury. Graphical Abstract: UF0001