A new 26-norlanostane from Phlogacanthus turgidus growing in Vietnam. Issue 2 (10th January 2022)

• Record Type: Journal Article
• Authors: Tri, Mai Dinh; Phat, Nguyen Tan; Trung, Nguyen Tien; Phan, Cam-Tu D.; Minh, Phan Nhat; Chi, Mai Thanh; Nguyen, Thi-Phuong; Dang, Chi Hien; Hong Truong, Luu; Pham, Nguyen Kim Tuyen; Mai, Trần Thị Ngọc; Duong, Thuc-Huy
• Is Part Of: Journal of Asian natural products research. Volume 24:Issue 2(2022)
• Page Start: 196
• Page End: 202
• Publication Date: 2022-01-10
• Subjects: Acanthaceae -- turgidol -- lupane -- Phlogacanthus turgidus -- DP4 probability -- lanostane; Materia medica -- Asia -- Periodicals; Pharmacognosy -- Asia -- Periodicals; Medicinal plants -- Asia -- Periodicals; Medicine, Oriental -- Asia -- Periodicals; 615.321095
• DOI: 10.1080/10286020.2021.1913125
• Languages: English
• ISSNs: 1028-6020

Abstract

Abstract: Chemical investigation on chloroform extract of Phlogacanthus turgidus led to the isolation of one new compound namely turgidol, together with five known triterpenoids, lupeol, lupenone, betulin, betulinic acid, and taraxerol. Their structures and stereochemistry have been determined by 1 D and 2 D NMR analysis, high resolution mass spectrometry, and compared with those in literatures. The relative configuration of turgidol was defined using DFT-NMR chemical shift calculations and subsequent DP4+ probability method. Turgidol, betulin, and betulinic acid were evaluated for cytotoxic activity toward K562 cancer cell line and the alpha-glucosidase inhibition. Graphical Abstract: UF0001