Chronic myeloid leukemia with pure erythroid leukemia blast crisis. Issue 1 (2nd January 2022)

• Record Type: Journal Article
• Authors: Jacobs, Jeremy W.; Ramaswamy, Rahul; States, Vanessa; Reppucci, Jennifer; Oluwole, Olalekan O.; Mason, Emily F.; Thompson, Mary Ann
• Is Part Of: Leukemia & lymphoma. Volume 63:Issue 1(2022)
• Page Start: 212
• Page End: 216
• Publication Date: 2022-01-02
• Subjects: Pure erythroid leukemia -- chronic myeloid leukemia -- myeloproliferative neoplasm -- blast crisis -- acute erythroid leukemia; Leukemia -- Periodicals; Lymphomas -- Periodicals; 616.99419
• DOI: 10.1080/10428194.2021.1975191
• Languages: English
• ISSNs: 1042-8194

Abstract

Abstract: Chronic myeloid leukemia (CML), a myeloproliferative neoplasm defined by the presence of the BCR-ABL1 oncogene created by the reciprocal translocation t (9;22)(q34.1;q11.2), can often be controlled by medications that inhibit this constitutive tyrosine kinase. However, if these therapies fail, the disease may progress to a form resembling an acute leukemia. While most of these CML 'blast crises' are characterized by blasts with a myeloid (granulocytic) or lymphoid lineage, these blasts may rarely be predominantly erythroid. Cases of CML erythroid blast crises have been reported; however, secondary pure erythroid leukemia arising from a CML blast crisis has only been definitively reported once before. We report the second definitive case of pure erythroid leukemia with the t (9;22)(q34.1;q11.2) presenting as a CML blast crisis and characterize the morphologic, immunophenotypic, flow cytometric, cytogenetic, and molecular findings.