Understanding the role of genetic susceptibility (ACE2 and TMPRSS2) in COVID-19. Issue 1 (31st December 2022)

• Record Type: Journal Article
• Authors: Aborode, Abdullahi Tunde; Onigbinde, Sherifdeen Bamidele; Sanusi, Khadijah Omoshalewa; Alaba, Noah; Rasaq-Lawal, Aderinola H.; Obadawo, Babatunde Samuel; Olatoyosi, Allison; Adeniran-Obey, Saidat Omowunmi; Onwukwe, Victor; Asogwa, Uchenna; Arinola, Ridwan Iyanu; Imani, Seun Idowu; Fasawe, Ayoola S.; Sodiya, Ibukunoluwa; Adeyemi, Sherif Babatunde; El-Saber Batiha, Gaber
• Is Part Of: Egyptian journal of basic and applied sciences. Volume 9:Issue 1(2022)
• Page Start: 43
• Page End: 50
• Publication Date: 2022-12-31
• Subjects: Genetics -- susceptibility -- COVID-19 -- ACE2 -- TMPRSS2; Science -- Periodicals; Technology -- Periodicals; Technology; Science; Science; Electronic journals; Periodicals; Periodical; 505
• DOI: 10.1080/2314808X.2021.1995309
• Languages: English
• ISSNs: 2314-808X

Abstract

ABSTRACT: COVID-19-related morbidity and mortality are significantly increased with increasing age and the presence of co-existing health conditions, such as cancer and cardiovascular disease. While most infected people recover, even very young and otherwise healthy patients may unpredictably succumb to this disease. COVID-19 is highly susceptible to Angiotensin-converting enzyme 2 (ACE2) and Transmembrane protease-serine 2 (TMPRSS2) polymorphisms altering the angiotensinogen-ACE2 interactions, such as p. Arg514Gly and its prevalence. The article describes the role of understanding the genetic basis of COVID-19 and its susceptibility to human genes.