Circulating chemerin levels in women with polycystic ovary syndrome: a meta-analysis. (2nd January 2022)

• Record Type: Journal Article
• Authors: Wang, Xin; Zhang, Qi; Zhang, Lin; Wei, Wenjing; Liu, Leliang; Li, Beibei; Zhang, Liao; Zhang, Ying; Hui, Yuyu; Lei, Ye
• Is Part Of: Gynecological endocrinology. Volume 38:Number 1(2022)
• Page Start: 22
• Page End: 27
• Publication Date: 2022-01-02
• Subjects: Chemerin -- polycystic ovary syndrome -- meta-analysis -- adipokine -- inflammation -- homeostatic model assessment of insulin resistance; Endocrine gynecology -- Periodicals; Generative organs, Female -- Diseases -- Periodicals; 618.1
• DOI: 10.1080/09513590.2021.1963431
• Languages: English
• ISSNs: 0951-3590

Abstract

Abstract: Objective: The present meta-analysis was conducted to investigate the association between circulating chemerin levels and polycystic ovary syndrome (PCOS) in women. Methods: Relevant studies published up to May 2020 were searched from PubMed, Ovid, the Cochrane Library, and Clinical Trial Database. A random effects model was used to measure the strength of association between PCOS and chemerin by using the standardized mean difference (SMD) and 95% confidence interval (CI). All data were analyzed using Stata 12.0 (version 12; Stata-Corp, College Station, TX). Results: The final meta-analysis included eight studies with 15 results including a total of 897 participants (524 patients with PCOS and 373 controls). The circulating chemerin levels were higher in patients with PCOS (random effects SMD = 1.07; 95% CI: 0.55–1.59; p < .001) than in controls. However, considerable heterogeneity across studies was not eliminated in subgroup analyses. The meta-regression analysis further suggested that region is the main source of heterogeneity ( p = .001). Conclusions: Our meta-analysis indicated that women with PCOS have significantly higher circulating chemerin levels than in healthy women, indicating that chemerin may be involved in the pathogenesis of PCOS.