Rhodium(iii)-catalyzed oxidative annulation of isoquinolones with allyl alcohols: synthesis of isoindolo[2, 1-b]isoquinolin-5(7H)-ones. Issue 2 (15th December 2021)

• Record Type: Journal Article
• Authors: Jiang, Jinyuan; Liu, Jidan; Yang, Zhenke; Zheng, Jieying; Tian, Xin; Zheng, Liyao; Liu, Zhao-Qing
• Is Part Of: Organic & biomolecular chemistry. Volume 20:Issue 2(2021)
• Page Start: 339
• Page End: 344
• Publication Date: 2021-12-15
• Subjects: Chemistry, Organic -- Periodicals; Bioorganic chemistry -- Periodicals; Chemistry, Physical organic -- Periodicals; 547
• DOI: 10.1039/d1ob02305e
• Languages: English
• ISSNs: 1477-0520

Abstract

Abstract : An efficient method to construct isoindolo[2, 1- b ]isoquinolin-5(7 H )-ones via a Rh(iii )-catalyzed direct C–H oxidative annulation of isoquinolones with allyl alcohols has been developed. Abstract : An efficient rhodium(iii )-catalyzed direct C–H oxidative annulation of isoquinolones with allyl alcohols as C1 synthons has been successfully developed. This protocol enables the straightforward synthesis of structurally diverse isoindolo[2, 1- b ]isoquinolin-5(7 H )-ones with high atom economy, tolerates a broad spectrum of functionalities, and is applicable to one-pot operation from readily available N -methoxybenzamides.