Postmortem diagnosis of Factor V Leiden from paraffin wax embedded tissue. Issue 3 (June 1996)

• Record Type: Journal Article
• Authors: Webb, J S; Standen, G R; Collins, C M P; Case, C P
• Is Part Of: Journal of clinical pathology. Volume 49:Issue 3(1996)
• Page Start: M180
• Page End: M181
• Publication Date: 1996-06
• Subjects: Factor V Leiden; thromboembolism; thrombophilia disorder; Pathology -- Periodicals; Pathology, Molecular -- Periodicals; 616.0705
• DOI: 10.1136/mp.49.3.M180
• Languages: English
• ISSNs: 0021-9746

Abstract

Abstract : Activated protein C resistance resulting from Factor V Leiden is an important inherited thrombophilia disorder which is found in 3.5% of people in the UK. The genetic defect can be detected using the PCR and the diagnosis can be made postmortem from paraffin wax embedded tissue. The presence of Factor V Leiden should be sought in all cases of unexplained sudden death resulting from venous thromboembolism.