Conformational Adaptation of β‐Peptide Foldamers for the Formation of Metal–Peptide Frameworks. (28th September 2021)

• Record Type: Journal Article
• Authors: Jeong, Seoneun; Zhang, Lianjin; Kim, Jaewook; Gong, Jintaek; Choi, Jonghoon; Ok, Kang Min; Lee, Yunho; Kwon, Sunbum; Lee, Hee‐Seung
• Is Part Of: Angewandte Chemie. Volume 134:Number 1(2022)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2021-09-28
• Subjects: coordination polymers -- foldamers -- metal–peptide frameworks; Chemistry -- Periodicals; 540
• DOI: 10.1002/ange.202108364
• Languages: English
• ISSNs: 0044-8249

Abstract

Abstract: Metal‐coordinated frameworks derived from small peptidic ligands have received much attention thanks to peptides' vast structural and functional diversity. Various peptides with partial conformational preferences have been used to build metal–peptide frameworks, however, the use of conformationally constrained β‐peptide foldamers has not been explored yet. Herein we report the first metal‐coordination‐mediated assembly of β‐peptide foldamers with 12‐helical folding propensity. The coordination of Ag + to the terminal pyridyl moieties afforded a set of metal–peptide frameworks with unique entangled topologies. Interestingly, formation of the network structures was accompanied by notable conformational distortions of the foldamer ligands. As the first demonstration of new metal–peptide frameworks built from modular β‐peptide foldamers, we anticipate that this work will be an important benchmark for further structural evolution and mechanistic investigation. Abstract : Ag + ‐coordination‐mediated assembly of β‐peptide foldamers led to the formation of distinctive metal–peptide frameworks with unique interwoven topologies. Formation of the network structures was accompanied by unusual conformational distortions of the foldamer ligands. These new metal–peptide frameworks built from modular foldamers may provide useful molecular platforms for further structural evolution and mechanistic investigation.