Can folate replacement induce lymphoma progression?. (6th August 2018)

• Record Type: Journal Article
• Authors: Ariyoshi, Nobuhiro; Hiraoka, Eiji; Koyamada, Ryosuke
• Is Part Of: BMJ case reports. Volume 2018
• Publication Date: 2018-08-06
• Subjects: malnutrition -- vitamins and supplements; Medicine -- Case studies -- Periodicals; 610.5
• DOI: 10.1136/bcr-2018-225482
• Languages: English
• ISSNs: 1757-790X

Abstract

Abstract : A 43-year-old Japanese man with a low haemoglobin level of 1.3 g/dL and multiorgan dysfunction syndrome (MODS) was admitted to our hospital. He was diagnosed with folate deficiency, which was initially attributed to his malnutrition. He was transfused with several units of packed red blood cells and treated with folate, thiamine and vitamin B12 supplements; he showed a prompt haematological response and recovery from MODS. However, 3 weeks after the initial recovery, he had a relapse of pancytopenia and developed high-grade fever along with rapidly enlarging, generalised lymphadenopathy. Bone marrow biopsy revealed hemophagocytosis, and lymph node biopsy revealed peripheral T-cell lymphoma, not otherwise specified. Folate supplementation may have promoted lymphoma progression.