A new type of membrane contact in the ER-Golgi system regulates autophagosome biogenesis. Issue 12 (2nd December 2021)

• Record Type: Journal Article
• Authors: Li, Shulin; Zhang, Min; Ge, Liang
• Is Part Of: Autophagy. Volume 17:Issue 12(2021)
• Page Start: 4499
• Page End: 4501
• Publication Date: 2021-12-02
• Subjects: Autophagosome -- autophagy -- COPII -- ERES -- ERGIC -- SEC12 -- TMED9; Autophagic vacuoles -- Periodicals; Apoptosis -- Periodicals; Cell death -- Periodicals; Lysosomes -- Periodicals; Degeneration (Pathology) -- Periodicals; Autophagy -- Periodicals; Cell Death -- Periodicals; Lysosomes -- Periodicals; Periodicals; 571.936
• DOI: 10.1080/15548627.2021.1972406
• Languages: English
• ISSNs: 1554-8627

Abstract

ABSTRACT: Formation of the double-membrane autophagosome requires membrane reorganization of the endomembrane system to generate membrane precursors. The ER-Golgi trafficking system has been shown to provide membranes for phagophore growth. Nonetheless, how the components of the ER-Golgi system are redirected toward autophagosome biogenesis remains unclear. Here, we identify a new type of membrane contact formed between the ER-Golgi intermediate compartment (ERGIC) and the ER-exit sites (ERES) under macroautophagy/autophagy-induction conditions. The ERGIC-ERES contact is established by the TMED9-PREB/SEC12 interaction and regulates the biogenesis of the ERGIC-COPII vesicles, which we found previously act as a membrane template for LC3 lipidation and autophagosome formation.