Thiamine hydrochloride as a recyclable organocatalyst for the efficient and chemoselective N-tert-butyloxycarbonylation of amines. Issue 24 (17th December 2021)

• Record Type: Journal Article
• Authors: Ingale, Ajit P.; Garad, Dnyaneshwar N.; Ukale, Dattatraya; Thorat, Nitin M.; Shinde, Sandeep V.
• Is Part Of: Synthetic communications. Volume 51:Issue 24(2021)
• Page Start: 3791
• Page End: 3804
• Publication Date: 2021-12-17
• Subjects: Chemoselective -- eco-friendly -- N-tert butyloxycarbonylation -- recyclable -- thiamin hydrochloride; Organic compounds -- Synthesis -- Periodicals; Chemistry, Organic; Synthesis; 547.205
• DOI: 10.1080/00397911.2021.1994998
• Languages: English
• ISSNs: 0039-7911

Abstract

Abstract: Thiamin hydrochloride promoted highly efficient and ecofriendly approach has been described for the chemoselective N - tert -butyloxycarbonylation of amines under solvent-free conditions at ambient temperature. The demonstrated approach has been applicable for the N- Boc protection of variety of aliphatic, aryl, heteroaryl amines. The chemoselective protection of amino group occurs in chiral amines and amino alcohol without racemization in high yield. Thiamin hydrochloride is stable, economical, easy to handle and environmentally friendly. Graphical Abstract: UF0001