Relationship of Epiretinal Membrane Formation and Macular Edema Development in a Large Cohort of Uveitic Eyes. (4th July 2021)

• Record Type: Journal Article
• Authors: Mustafi, Debarshi; Do, Brian K.; Rodger, Damien C.; Rao, Narsing A.
• Is Part Of: Ocular immunology and inflammation. Volume 29:Number 5(2021)
• Page Start: 915
• Page End: 921
• Publication Date: 2021-07-04
• Subjects: Epiretinal membrane -- macular edema -- ocular inflammation -- spectral domain-optical coherence tomography -- uveitis; Eye -- Diseases -- Immunological aspects -- Periodicals; Eye -- Inflammation -- Periodicals; 617.7
• DOI: 10.1080/09273948.2019.1704026
• Languages: English
• ISSNs: 0927-3948

Abstract

ABSTRACT: Purpose : To identify the temporal relationship and clinical characteristics of epiretinal membrane (ERM) and macular edema (ME) formation in uveitic eyes. Methods : A total of 269 subjects (444 uveitic eyes) met study inclusion criteria. Comprehensive ophthalmic examination, spectral domain-optical coherence tomography (SD-OCT), and clinical testing were carried out. Results : Of the 444 uveitic eyes, 229 eyes (51.6%) developed an ERM, whereas 87 eyes (19.1%) developed ME. The odds ratios (ORs) of systemic disease causing uveitis and resulting in ERM and ME were significantly higher in posterior uveitis (OR 6.56, 95% CI 2.98–14.46; p < .0001) and panuveitis (OR 10.09, 95% CI 4.05–25.15; p < .0001). Temporal analysis revealed that an ERM was noted concurrently or prior to ME development in 93.8% of eyes. Conclusions : ERM and ME are primarily observed in posterior uveitis and panuveitis associated with systemic diseases. The temporal relationship highlights the importance of characterization of ERM as it relates to the development of uveitic ME.