Electrochemical regioselective C–H selenylation of 2H-indazole derivatives. Issue 1 (6th December 2021)

• Record Type: Journal Article
• Authors: Lin, Shengsheng; Cheng, Xiaomei; Hasimujiang, Balati; Xu, Zhongnan; Li, Fengtan; Ruan, Zhixiong
• Is Part Of: Organic & biomolecular chemistry. Volume 20:Issue 1(2021)
• Page Start: 117
• Page End: 121
• Publication Date: 2021-12-06
• Subjects: Chemistry, Organic -- Periodicals; Bioorganic chemistry -- Periodicals; Chemistry, Physical organic -- Periodicals; 547
• DOI: 10.1039/d1ob02108g
• Languages: English
• ISSNs: 1477-0520

Abstract

Abstract : A metal- and oxidant-free, electrochemical strategy for the regioselective selenylation of 2 H -indazole derivatives has been developed, with broad substrate scope and moderate to good yields, under mild and environment-friendly reaction conditions. Abstract : Selenium-substituted heteroarenes are biologically active compounds and useful building blocks. In this study, we have developed a metal- and oxidant-free, environmentally friendly protocol for the regioselective selenylation of 2 H -indazole derivatives by an electrochemical strategy. A number of selenylated 2 H -indazoles with a wide range of functional groups have been synthesized in moderate to good yields under mild and environment-friendly reaction conditions.