61 Cervical dysplasia among long-term screening non-attendees – a swedish population. (18th September 2019)

• Record Type: Journal Article
• Authors: Borgfeldt, C; Ernstson, A; Forslund, O
• Is Part Of: International journal of gynecological cancer. Volume 29(2019)Supplement 3
• Page Start: A33
• Page End: A34
• Publication Date: 2019-09-18
• Subjects: Generative organs, Female -- Cancer -- Periodicals; 616.99465
• DOI: 10.1136/ijgc-2019-IGCS.61
• Languages: English
• ISSNs: 1048-891X

Abstract

Abstract : Objectives: The efficacy of cervical screening programs is dependent on the participation rate which in Sweden is 83%. To increase participation among women not attending to cervical screening, self-collected samples for detection of high-risk human papillomavirus is an option. The aims were to investigate the response rate of a self-collected vaginal HPV sample sent to long-term non-attendees and the prevalence of cervical dysplasia among the responders. Methods: A vaginal HPV self-sampling kit was sent to 19, 766 women aged 30–70 years with no cervical screening sample for ³7 years. The self-sample was analyzed by Aptima HPV mRNA assay (Hologic). Women positive for HPV mRNA were invited for follow-up. Results: The response rate of the self-collected vaginal HPV sample was 18.5% (3652/19, 766). The prevalence of HPV mRNA was 11.0% (402/3, 652). The histo-pathologically confirmed prevalence of HSIL or cancer was 7.7% (31/402) in the HPV positive women and in the whole group of responders 0.85% (31/3, 652), including two cervical and one vaginal cancer. Conclusions: Self-collected vaginal HPV samples increased coverage in cervical screening among long time non-attendees. The prevalence of HPV mRNA was higher (11%) in long time non-attenders than in women attending the screening program within routine screening intervals (7%) (p<0.001), but the prevalence of HSIL and cervical cancer was similar as in regularly screened women.