COVID-19 Severity in Multiple Sclerosis: Putting Data Into Context. Issue 1 (9th January 2022)

• Record Type: Journal Article
• Authors: Sormani, Maria Pia; Schiavetti, Irene; Carmisciano, Luca; Cordioli, Cinzia; Filippi, Massimo; Radaelli, Marta; Immovilli, Paolo; Capobianco, Marco; De Rossi, Nicola; Brichetto, Giampaolo; Cocco, Eleonora; Scandellari, Cinzia; Cavalla, Paola; Pesci, Ilaria; Zito, Antonio; Confalonieri, Paolo; Marfia, Girolama Alessandra; Perini, Paola; Inglese, Matilde; Trojano, Maria; Brescia Morra, Vincenzo; Tedeschi, Gioacchino; Comi, Giancarlo; Battaglia, Mario Alberto; Patti, Francesco; Salvetti, Marco
• Other Names: author non-byline.; Abbadessa Gianmarco author non-byline.; Aguglia Umberto author non-byline.; Allegorico Lia author non-byline.; Allegri Rossi Beatrice Maria author non-byline.; Amato Maria Pia author non-byline.; Annovazzi Pietro author non-byline.; Antozzi Carlo author non-byline.; Appendino Lucia author non-byline.; Arena Sebastiano author non-byline.; Baione Viola author non-byline.; Balgera Roberto author non-byline.; Barcella Valeria author non-byline.; Baroncini Damiano author non-byline.; Barrilà Caterina author non-byline.; Bellacosa Alessandra author non-byline.; Bellucci Gianmarco author non-byline.; Bergamaschi Roberto author non-byline.; Bergamaschi Valeria author non-byline.; Bezzini Daiana author non-byline.; Biolzi Beatrice author non-byline.; Bisecco Alvino author non-byline.; Bonavita Simona author non-byline.; Borriello Giovanna author non-byline.; Bosa Chiara author non-byline.; Bosco Antonio author non-byline.; Bovis Francesca author non-byline.; Bozzali Marco author non-byline.; Brambilla Laura author non-byline.; Buccafusca Maria author non-byline.; Bucciantini Elisabetta author non-byline.; Bucello Sebastiano author non-byline.; Buscarinu Maria Chiara author non-byline.; Cabboi Maria Paola author non-byline.; Calabrese Massimiliano author non-byline.; Calabria Francesca author non-byline.; Caleri Francesca author non-byline.; Camilli Federico author non-byline.; Caniatti Luisa Maria author non-byline.; Cantello Roberto author non-byline.; Capra Ruggero author non-byline.; Capuano Rocco author non-byline.; Carta Patrizia author non-byline.; Celani Maria Grazia author non-byline.; Cellerino Maria author non-byline.; Cerqua Raffaella author non-byline.; Chisari Clara author non-byline.; Clerici Raffaella author non-byline.; Clerico Marinella author non-byline.; Cola Gaia author non-byline.; Conte Antonella author non-byline.; Conti Marta Zaffira author non-byline.; Cordano Christian author non-byline.; Cordera Susanna author non-byline.; Corea Francesco author non-byline.; Correale Claudio author non-byline.; Cottone Salvatore author non-byline.; Crescenzo Francesco author non-byline.; Curti Erica author non-byline.; d'Ambrosio Alessandro author non-byline.; D'Amico Emanuele author non-byline.; Danni Maura Chiara author non-byline.; d'Arma Alessia author non-byline.; Dattola Vincenzo author non-byline.; de Biase Stefano author non-byline.; Luca Giovanna De author non-byline.; Mercanti Stefania Federica De author non-byline.; De Mitri Paolo author non-byline.; De Stefano Nicola author non-byline.; Cava Marco Della author non-byline.; Napoli Mario di author non-byline.; Sapio Alessia Di author non-byline.; Docimo Renato author non-byline.; Dutto Anna author non-byline.; Evangelista Luana author non-byline.; Fanara Salvatore author non-byline.; Diana Ferraro author non-byline.; Ferrò Maria Teresa author non-byline.; Fioretti Cristina author non-byline.; Fratta Mario author non-byline.; Frau Jessica author non-byline.; Fronza Marzia author non-byline.; Furlan Roberto author non-byline.; Gajofatto Alberto author non-byline.; Gallo Antonio author non-byline.; Gallo Paolo author non-byline.; Gasperini Claudio author non-byline.; Ghazaryan Anna author non-byline.; Giometto Bruno author non-byline.; Gobbin Francesca author non-byline.; Govone Flora author non-byline.; Granella Franco author non-byline.; Grange Erica author non-byline.; Grasso Maria Grazia author non-byline.; Guareschi Angelica author non-byline.; Guaschino Clara author non-byline.; Guerrieri Simone author non-byline.; Guidetti Donata author non-byline.; Iaffaldano Pietro author non-byline.; Ianniello Antonio author non-byline.; Iasevoli Luigi author non-byline.; Imperiale Daniele author non-byline.; Infante Maria Teresa author non-byline.; Iodice Rosa author non-byline.; Iovino Aniello author non-byline.; Konrad Giovanna author non-byline.; Landi Doriana author non-byline.; Lanzillo Roberta author non-byline.; Lapucci Caterina author non-byline.; Lavorgna Luigi author non-byline.; L'Episcopo Maria Rita author non-byline.; Leva Serena author non-byline.; Liberatore Giuseppe author non-byline.; Lo Re Marianna author non-byline.; Longoni Marco author non-byline.; Lopiano Leonardo author non-byline.; Lorefice Lorena author non-byline.; Lucchini Matteo author non-byline.; Lus Giacomo author non-byline.; Maimone Davide author non-byline.; Malentacchi Maria author non-byline.; Mallucci Giulia author non-byline.; Malucchi Simona author non-byline.; Mancinelli Chiara Rosa author non-byline.; Mancinelli Luca author non-byline.; Manganotti Paolo author non-byline.; Maniscalco Giorgia Teresa author non-byline.; Mantero Vittorio author non-byline.; Marangoni Sabrina author non-byline.; Marastoni Damiano author non-byline.; Marinelli Fabiana author non-byline.; Marti Alessandro author non-byline.; Boneschi Filippo Martinelli author non-byline.; Masserano Zoli Federco author non-byline.; Matta Francesca author non-byline.; Mendozzi Laura author non-byline.; Meucci Giuseppe author non-byline.; Miante Silvia author non-byline.; Miele Giuseppina author non-byline.; Milano Eva author non-byline.; Mirabella Massimiliano author non-byline.; Missione Rosanna author non-byline.; Moccia Marcello author non-byline.; Moiola Lucia author non-byline.; Montepietra Sara author non-byline.; MontiBragadin Margherita author non-byline.; Montini Federico author non-byline.; Motta Roberta author non-byline.; Nardone Raffaele author non-byline.; Nicoletti Carolina Gabri author non-byline.; Nobile-Orazio Eduardo author non-byline.; Nozzolillo Agostino author non-byline.; Onofrj Marco author non-byline.; Orlandi Riccardo author non-byline.; Palmieri Anna author non-byline.; Paolicelli Damiano author non-byline.; Pasquali Livia author non-byline.; Pastò Luisa author non-byline.; Pedrazzoli Elisabetta author non-byline.; Petracca Maria author non-byline.; Petrone Alfredo author non-byline.; Piantadosi Carlo author non-byline.; Pietroboni Anna M author non-byline.; Pinardi Federica author non-byline.; Ponzano Marta author non-byline.; Portaccio Emilio author non-byline.; Pozzato Mattia author non-byline.; Pozzilli Carlo author non-byline.; Prosperini Luca author non-byline.; Protti Alessandra author non-byline.; Ragonese Paolo author non-byline.; Rasia Sarah author non-byline.; Realmuto Sabrina author non-byline.; Repice Anna author non-byline.; Rigoni Eleonora author non-byline.; Rilla Maria Teresa author non-byline.; Rinaldi Francesca author non-byline.; Romano Calogero Marcello author non-byline.; Ronzoni Marco author non-byline.; Rovaris Marco author non-byline.; Ruscica Francesca author non-byline.; Sabattini Loredana author non-byline.; Salemi Giuseppe author non-byline.; Saraceno Lorenzo author non-byline.; Sartori Alessia author non-byline.; Sartori Arianna author non-byline.; Sbragia Elvira author non-byline.; Scarano Giuditta Ilaria author non-byline.; Scarano Valentina author non-byline.; Schillaci Valentina author non-byline.; Sessa Maria author non-byline.; Sgarito Caterina author non-byline.; Sibilia Grazia author non-byline.; Siciliano Gabriele author non-byline.; Signori Alessio author non-byline.; Signoriello Elisabetta author non-byline.; Sinisi Leonardo author non-byline.; Sireci Francesca author non-byline.; Sola Patrizia author non-byline.; Solaro Claudio author non-byline.; Sotgiu Stefano author non-byline.; Sparaco Maddalena author non-byline.; Stromillo Maria Laura author non-byline.; Strumia Silvia author non-byline.; Susani Emanuela Laura author non-byline.; Tabiadon Giulietta author non-byline.; Teatini Francesco author non-byline.; Tomassini Valentina author non-byline.; Tonietti Simone author non-byline.; Torri Clerici Valentina author non-byline.; Tortorella Carla author non-byline.; Toscano Simona author non-byline.; Totaro Rocco author non-byline.; Trotta Maria author non-byline.; Turano Gabriella author non-byline.; Ulivelli Monica author non-byline.; Valentino Manzo author non-byline.; Vaula Giovanna author non-byline.; Vecchio Domizia author non-byline.; Vercellino Marco author non-byline.; Verrengia Elena Pinuccia author non-byline.; Vianello Marika author non-byline.; Virgilio Eleonora author non-byline.; Vitetta Francesca author non-byline.; Vollaro Stefano author non-byline.; Zaffaroni Mauro author non-byline.; Zampolini Mauro author non-byline.; Zarbo Ignazio Roberto author non-byline.; Zuliani Luigi author non-byline.;
• Is Part Of: Neurology. Volume 9:Issue 1(2022)
• Publication Date: 2022-01-09
• Subjects: Neuroimmunology -- Periodicals; Neurology -- Periodicals; 616.8
• DOI: 10.1212/NXI.0000000000001105
• Languages: English
• ISSNs: 2332-7812

Abstract

Abstract : Background and Objectives: It is unclear how multiple sclerosis (MS) affects the severity of COVID-19. The aim of this study is to compare COVID-19–related outcomes collected in an Italian cohort of patients with MS with the outcomes expected in the age- and sex-matched Italian population. Methods: Hospitalization, intensive care unit (ICU) admission, and death after COVID-19 diagnosis of 1, 362 patients with MS were compared with the age- and sex-matched Italian population in a retrospective observational case-cohort study with population-based control. The observed vs the expected events were compared in the whole MS cohort and in different subgroups (higher risk: Expanded Disability Status Scale [EDSS] score > 3 or at least 1 comorbidity, lower risk: EDSS score ≤ 3 and no comorbidities) by the χ 2 test, and the risk excess was quantified by risk ratios (RRs). Results: The risk of severe events was about twice the risk in the age- and sex-matched Italian population: RR = 2.12 for hospitalization ( p < 0.001), RR = 2.19 for ICU admission ( p < 0.001), and RR = 2.43 for death ( p < 0.001). The excess of risk was confined to the higher-risk group (n = 553). In lower-risk patients (n = 809), the rate of events was close to that of the Italian age- and sex-matched population (RR = 1.12 for hospitalization, RR = 1.52 for ICU admission, and RR = 1.19 for death). In the lower-risk group, an increased hospitalization risk was detected in patients on anti-CD20 (RR = 3.03, p = 0.005), whereas a decrease was detected in patients on interferon (0 observed vs 4 expected events, p = 0.04). Discussion: Overall, the MS cohort had a risk of severe events that is twice the risk than the age- and sex-matched Italian population. This excess of risk is mainly explained by the EDSS score and comorbidities, whereas a residual increase of hospitalization risk was observed in patients on anti-CD20 therapies and a decrease in people on interferon.