Potential of Donation After Unexpected Circulatory Death Programs Defined by Their Demographic Characteristics. Issue 1 (23rd December 2021)

• Record Type: Journal Article
• Authors: Brat, Aukje; Venema, Leonie H.; Bens, Bas W.J.; Stieglis, Remy; van der Heijden, Joris J.; Fondevila, Constantino; Reznik, Oleg N.; Barrou, Benoit; Erasmus, Michiel E.; Leuvenink, Henri G.D.
• Is Part Of: Transplantation direct. Volume 8:Issue 1(2022)
• Page Start: e1263
• Publication Date: 2021-12-23
• Subjects: Transplantation of organs, tissues, etc -- Periodicals; Transplantation -- Periodicals; 362.19795
• DOI: 10.1097/TXD.0000000000001263
• Languages: English
• ISSNs: 2373-8731

Abstract

Abstract : Background: Donation after unexpected circulatory death (uDCD) donors are often suggested to increase the number of donor organs. In 2014, a uDCD protocol was implemented in three transplant centers in the Netherlands which unfortunately did not result in additional transplantations. This study was initiated to identify demographic factors influencing the potential success of uDCD programs. Methods: Dutch resuscitation databases covering various demographic regions were analyzed for potential donors. The databases were compared with the uDCD implementation project and successful uDCD programs in Spain, France, and Russia. Results: The resuscitation databases showed that 61% of all resuscitated patients were transferred to an emergency department. Age selection reduced this uDCD potential to 46% with only patients aged 18–65 years deemed eligible. Of these patients, 27% died in the emergency department. The urban region of Amsterdam showed the largest potential in absolute numbers (52 patients/y). Comparison with the uDCD implementation project showed large similarities in the percentage of potential donors; however, in absolute numbers, it showed a much smaller potential. Calculation of the potential per million persons and the extrapolation of the potential based on the international experience revealed the largest potential in urban regions. Conclusions: Implementation of a uDCD program should not only be based on the number of potential donors calculated from resuscitation databases. They show promising potential uDCD percentages for large rural regions and small urban regions; however, actual numbers per hospital are low, leading to insufficient exposure rates. It is, therefore, recommendable to limit uDCD programs to large urban regions.