Receptors and ligands for herpes simplex viruses: Novel insights for drug targeting. Issue 1 (January 2022)

• Record Type: Journal Article
• Authors: Huang, Yiwei; Song, Yuyun; Li, Jichen; Lv, Changning; Chen, Zhe-Sheng; Liu, Zhijun
• Is Part Of: Drug discovery today. Volume 27:Issue 1(2022)
• Page Start: 185
• Page End: 195
• Publication Date: 2022-01
• Subjects: Herpes simplex virus -- Cellular receptor -- Glycoprotein -- Drugs; Drugs -- Design -- Periodicals; Drugs -- Research -- Periodicals; 615.1
• DOI: 10.1016/j.drudis.2021.10.004
• Languages: English
• ISSNs: 1359-6446

Abstract

Highlights: Better understanding of the cell receptors and ligands involved in HSV infection. Illustrating the process of HSV infection. The value of drugs targeting HSV entry process is highlighted. An attempt to curb the elevating risk of HSV for its high prevalence. Abstract: Human herpes simplex viruses (HSVs) belong to the Herpesviridae family. At present, no vaccine or curative treatment is available for the prevention of HSV infections. Here, we review the cell surface receptors that are recognized by HSV's glycoprotein B, glycoprotein C, glycoprotein D, and the glycoprotein H – glycoprotein L complex to facilitate entry into host cells. These receptors include heparan sulfate (HS), herpesvirus entry mediator (HVEM), and nectin-1/-2, 3- O -sulfated heparan sulfate (3- O S HS).