Clinical features of automatisms and correlation with the seizure onset zones: A cluster analysis of 74 surgically-treated cases. (January 2022)

• Record Type: Journal Article
• Authors: Yang, Bowen; Mo, Jiajie; Zhang, Chao; Wang, Xiu; Sang, Lin; Zheng, Zhong; Gao, Dongmei; Zhao, Xuemin; Wang, Yao; Liu, Chang; Zhao, Baotian; Guo, Zhihao; Shao, Xiaoqiu; Zhang, Jianguo; Zhang, Kai; Hu, Wenhan
• Is Part Of: Seizure. Volume 94(2022)
• Page Start: 82
• Page End: 89
• Publication Date: 2022-01
• Subjects: Focal seizures -- Semiology -- Automatisms -- Cluster analysis; Epilepsy -- Periodicals; Epilepsy -- Periodicals; Seizures -- Periodicals; Épilepsie -- Périodiques; Electronic journals; Electronic journals; 616.853
• DOI: 10.1016/j.seizure.2021.11.015
• Languages: English
• ISSNs: 1059-1311

Abstract

Highlights: Four clinical patterns of automatisms were identified by k-means cluster analysis. Automatisms from temporal and extratemporal localisations showed different semiologic features. Clinical patterns 1, 3, 4 were significantly correlated with mesial temporal lobe epilepsy (MTLE), frontal lobe epilepsy (FLE), and neocortical temporal lobe epilepsy (NTLE), respectively. Manual automatisms occurred earlier in the NTLE group and persisted longer in the MTLE group. MTLE had a significantly higher proportion of automatisms than other groups. Abstract: Objectives: To identify semiologic features of automatisms correlating to different seizure onset zones (SOZ). Methods: In total, 204 seizures from 74 patients with either oral or manual automatisms were assessed. Patients were divided into four groups depending on the SOZ into frontal, posterior, neocortical temporal, and mesial temporal cortex groups. A k-means analysis was applied on 11 semiologic features on a multi-criteria scale. Then, the resulting clinical patterns were correlated with the SOZs determined by presurgical anatomy-electroclinical data (25 cases with stereo-EEG). Results: Four clinical patterns of automatisms with different accompanying symptoms were identified. The clinical features of clusters 1 and 4 were mostly found in temporal epilepsy whereas clusters 2 and 3 were more frequent in extratemporal epilepsy. Cluster 1 was significantly correlated with mesial temporal lobe epilepsy ( p = .017) and was characterised by aura, postictal confusion, short automatisms delay. Cluster 3 included 1/3 patients with frontal lobe epilepsy and was characterised by emotionality. Cluster 4 was related to neocortical temporal lobe epilepsy and characterised by dystonia and short automatism delay ( p = .011). Conclusion: The distinct semiologic patterns of automatisms may provide information which may allow clinicians to define the SOZs. These findings could improve diagnostic accuracy and surgical outcome.