An automated radiosynthesis of [18F]DPA-714 on a commercially available radiosynthesizer, Elixys Flex/Chem. (February 2022)

• Record Type: Journal Article
• Authors: McCauley, Katelyenn S.; Wilde, Justin H.; Bufalino, Sophia M.; Neumann, Kiel D.
• Is Part Of: Applied radiation and isotopes. Volume 180(2022)
• Publication Date: 2022-02
• Subjects: Fluorine-18 -- F-18 -- Positron emission tomography -- Radiosynthesis -- Radiochemistry -- Automation; Radiology -- Periodicals; Radiation -- Industrial applications -- Periodicals; Nuclear chemistry -- Periodicals; Internet resource; Periodical; 660.298
• DOI: 10.1016/j.apradiso.2021.110032
• Languages: English
• ISSNs: 0969-8043

Abstract

Abstract: [ 18 F]DPA-714 is a radiotracer specific to the translocator protein (TSPO) and is useful for in vivo Positron Emission Tomography imaging studies. In this report, we have developed an automated radiosynthesis of [ 18 F]DPA-714 on a commercially-available radiosynthesis platform, which comports with USP <823> guidelines. The wide availability of the radiosynthesis module and ease of dissemination of the production sequence will facilitate preclinical and clinical research of TSPO-related pathology. Highlights: A USP <823> compliant [ 18 F]DPA-714 radiosynthesis is now available Synthesis of a radiochemical precursor is optimized Low yields of a radiochemical precursor were the result of an elimination product formed in situ