Individualized PID tuning for maintenance of general anesthesia with propofol and remifentanil coadministration. (January 2022)

• Record Type: Journal Article
• Authors: Schiavo, Michele; Padula, Fabrizio; Latronico, Nicola; Paltenghi, Massimiliano; Visioli, Antonio
• Is Part Of: Journal of process control. Volume 109(2022)
• Page Start: 74
• Page End: 82
• Publication Date: 2022-01
• Subjects: Depth of hypnosis control -- PID control -- Individualized drug administration -- Personalized medicine -- Propofol remifentanil coadministration; Process control -- Periodicals; Fabrication -- Contrôle -- Périodiques; Process control; Periodicals; Electronic journals; 660.281
• DOI: 10.1016/j.jprocont.2021.12.004
• Languages: English
• ISSNs: 0959-1524

Abstract

Abstract: In this paper we propose a methodology for a patient-individualized tuning of the parameters of a proportional–integral–derivative (PID) controller that regulates the depth of hypnosis in the maintenance phase of general anesthesia. In particular, we consider a PID controller employed in a closed-loop multiple-input–single-output (MISO) control system for propofol and remifentanil coadministration. Simulation results show that the approach provides an increased robustness with respect to both intra-patient and inter-patient compared to a population-based tuning. This is obtained at the cost of a slight decrement of the controller bandwidth that causes a minor increment of the time required to reject disturbances.