Multidrug Resistant Tuberculosis With Simultaneously Acquired Drug Resistance to Bedaquiline and Delamanid. (30th July 2020)

• Record Type: Journal Article
• Authors: Yoshiyama, Takashi; Takaki, Akiko; Aono, Akio; Mitarai, Satoshi; Okumura, Masao; Ohta, Ken; Kato, Seiya
• Is Part Of: Clinical infectious diseases. Volume 73:Number 12(2021)
• Page Start: 2329
• Page End: 2331
• Publication Date: 2020-07-30
• Subjects: tuberculosis -- acquired drug resistance -- bedaquiline -- delamanid; Communicable diseases -- Periodicals; 616.905
• DOI: 10.1093/cid/ciaa1064
• Languages: English
• ISSNs: 1058-4838

Abstract

Abstract: This study is the first to report a clinical case of simultaneously acquired resistance to bedaquiline (BDQ) and delamanid (DLM). Whole genome sequencing revealed 2 nucleotide insertions (Rv0678 and fbiC) in the Mycobacterium tuberculosis isolate. The minimum inhibitory concentrations for BDQ and DLM were 0.25 µg/mL and >2.0 µg/mL, respectively.