Serological Profiling of Group A Streptococcus Infections in Acute Rheumatic Fever. (26th February 2021)

• Record Type: Journal Article
• Authors: Lorenz, Natalie; Ho, Timothy K C; McGregor, Reuben; Davies, Mark R; Williamson, Deborah A; Gurney, Jason K; Smeesters, Pierre R; Baker, Michael G; Moreland, Nicole J
• Is Part Of: Clinical infectious diseases. Volume 73:Number 12(2021)
• Page Start: 2322
• Page End: 2325
• Publication Date: 2021-02-26
• Subjects: rheumatic fever -- group A Streptococcus -- immune priming -- emm-type -- emm-cluster; Communicable diseases -- Periodicals; 616.905
• DOI: 10.1093/cid/ciab180
• Languages: English
• ISSNs: 1058-4838

Abstract

Abstract: Rheumatic fever is a serious post-infectious sequela of group A Streptococcus (GAS). Prior GAS exposures were mapped in sera using a large panel of M-type specific peptides. Rheumatic fever patients had serological evidence of significantly more GAS exposures than matched controls suggesting immune priming by repeat infections contributes to pathogenesis.