Nano-structured myelin: new nanovesicles for targeted delivery to white matter and microglia, from brain-to-brain. (September 2021)

• Record Type: Journal Article
• Authors: Picone, Pasquale; Palumbo, Fabio Salvatore; Federico, Salvatore; Pitarresi, Giovanna; Adamo, Giorgia; Bongiovanni, Antonella; Chaves, Antonio; Cancemi, Patrizia; Muccilli, Vera; Giglio, Valentina; Vetri, Valeria; Anselmo, Sara; Sancataldo, Giuseppe; Di Liberto, Valentina; Nuzzo, Domenico
• Is Part Of: Materials today bio. Volume 12(2021)
• Publication Date: 2021-09
• Subjects: Nanovesicles -- Myelin nanovesicles -- Brain delivery -- Withe matter -- Microglia cells; Materials science -- Periodicals; Biomedical engineering -- Periodicals; Biomedical materials -- Periodicals; 620.1
• DOI: 10.1016/j.mtbio.2021.100146
• Languages: English
• ISSNs: 2590-0064

Abstract

Abstract: Neurodegenerative diseases affect millions of people worldwide and the presence of various physiological barriers limits the accessibility to the brain and reduces the efficacy of various therapies. Moreover, new carriers having targeting properties to specific brain regions and cells are needed in order to improve therapies for the brain disorder treatment. In this study, for the first time, Myelin nanoVesicles (hereafter defined MyVes) from brain-extracted myelin were produced. The MyVes have an average diameter of 100–150 ​nm, negative zeta potential, spheroidal morphology, and contain lipids and the key proteins of the myelin sheath. Furthermore, they exhibit good cytocompatibility. The MyVes were able to target the white matter and interact mainly with the microglia cells. The preliminary results here presented allow us to suppose the employment of MyVes as potential carrier to target the white matter and microglia in order to counteract white matter microglia-related diseases. Graphical abstract: Image 1 Highlights: Bio-fabrication of brain tissue derived nanovesicles: myelin nanovesicles. Myelin nanovesicles contain the main proteins of the myelin sheath (myelin basic protein and myelin proteolipid protein). Myelin nanovesicles can lade a drug/molecule and cross a blood–brain barrier model. Myelin nanovesicles target white matter and microglia cells.