'Scary' pericytes: the fibrotic scar in brain and spinal cord lesions. Issue 1 (January 2022)

• Record Type: Journal Article
• Authors: Rentsch, Nora H.; Rust, Ruslan
• Is Part Of: Trends in neurosciences. Volume 45:Issue 1(2022)
• Page Start: 6
• Page End: 7
• Publication Date: 2022-01
• Subjects: type A pericytes -- scarring -- glial scar -- central nervous system -- CNS injury -- regeneration; Neurology -- Periodicals; Neurophysiology -- Periodicals; Neurobiology -- Periodicals; 612.8
• DOI: 10.1016/j.tins.2021.10.013
• Languages: English
• ISSNs: 0166-2236

Abstract

Abstract : Scar tissue presents a barrier to regeneration in the central nervous system (CNS). Although the glial scar has been extensively studied, recent evidence suggests that non-glial components are also involved. In a recent paper, Dias, Kalkitsas, and colleagues uncovered a subset of pericytes as a contributor to fibrotic scarring that is conserved across diverse CNS lesions.