Platelet infiltration predicts survival in postsurgical colorectal cancer patients. Issue 3 (19th October 2021)

• Record Type: Journal Article
• Authors: Miao, Yiming; Xu, Zifeng; Feng, Wenqing; Zheng, Minhua; Xu, Zhuoqing; Gao, Han; Li, Wenchang; Zhang, Yuchen; Zong, Yaping; Lu, Aiguo; Zhao, Jingkun
• Is Part Of: International journal of cancer. Volume 150:Issue 3(2022)
• Page Start: 509
• Page End: 520
• Publication Date: 2021-10-19
• Subjects: colorectal cancer -- disease‐free survival -- overall survival -- platelet infiltration -- prognostic prediction; Cancer -- Periodicals; Cancer -- Prevention -- Periodicals; 616.994
• DOI: 10.1002/ijc.33816
• Languages: English
• ISSNs: 0020-7136

Abstract

Abstract: Platelets promote tumor growth and metastasis in several tumor types. Recent research has found platelets can extravasate and infiltrate into the tumor stroma and interact with the tumor microenvironment. The prognostic role of platelet infiltration in colorectal cancer (CRC) remains controversial. A pan‐cancer survival analysis was performed to find the potential prognostic value of platelet infiltration in patients with cancer. A survival analysis and a nomogram prognostic model were established to further confirm the results with data from our center. The correlations between patient outcomes and tumor‐infiltrating platelets (TIPs) were identified by immunohistochemical staining for CD42b. The prognostic accuracy and discriminative ability of the nomogram were determined by the concordance index (C‐index) and a calibration curve. The pan‐cancer survival analysis showed platelet infiltration can lead to a poor prognosis in patients with several types of cancers, including CRC. Platelet infiltration was associated with overall survival (OS) and disease‐free survival (DFS) in both primary and validation cohorts. The C‐index values of the nomogram for predicting OS and DFS were 0.774 and 0.769, respectively, which were higher than that of the TNM staging system alone. Our study found platelet infiltration has a potential prognostic value regarding postsurgical survival in CRC patients. The proposed nomogram resulted in a more accurate prognostic prediction for postsurgical CRC patients. Abstract : What's new? Recent research has increasingly linked the tumor microenvironment with tumor progression and metastasis. Platelets are known to infiltrate and interact with the tumor microenvironment. In this study, the authors found that platelet infiltration correlated with poor prognosis in several types of cancer. They then validated their analysis in tumors from colorectal cancer (CRC) patients. Platelet infiltration was associated with decreased postsurgical survival, and this measure was more accurate than TMN staging alone. Platelet infiltration might therefore offer a useful prognostic biomarker for postsurgical CRC patients.