Increased 5-year risk of stroke, atrial fibrillation, acute coronary syndrome, and heart failure in out-of-hospital cardiac arrest survivors compared with population controls: A nationwide registry-based study. (December 2021)

• Record Type: Journal Article
• Authors: Byrne, Christina; Pareek, Manan; Krogager, Maria Lukacs; Ringgren, Kristian B.; Wissenberg, Mads; Folke, Fredrik; Lippert, Freddy; Gislason, Gunnar; Køber, Lars; Søgaard, Peter; Lip, Gregory Y.H.; Torp-Pedersen, Christian; Kragholm, Kristian
• Is Part Of: Resuscitation. Volume 169(2021)
• Page Start: 53
• Page End: 59
• Publication Date: 2021-12
• Subjects: Out-of-hospital cardiac arrest survivors -- Long-term risk -- Stroke -- Atrial fibrillation and atrial flutter -- Acute coronary syndrome -- Heart failure; Resuscitation -- Periodicals; Resuscitation -- Periodicals; Réanimation -- Périodiques; Electronic journals; 616.025
• DOI: 10.1016/j.resuscitation.2021.10.024
• Languages: English
• ISSNs: 0300-9572

Abstract

Abstract: Aim: Long-term risks of stroke, atrial fibrillation, or flutter (AF), acute coronary syndrome (ACS), and heart failure (HF) among survivors of out-of-hospital cardiac arrest (OHCA) are unknown. We aimed to examine 5-year risks of these outcomes among 30-day survivors of OHCA. Methods: Thirty-day survivors of OHCA without a prior (or within 30 days after cardiac arrest) history of stroke, AF, ACS, or HF and population controls without a prior history of these conditions were identified using Danish nationwide registries. Five-year risks of stroke, AF, ACS, and HF standardized to the distributions of age, sex, and comorbidities among OHCA survivors and controls were obtained using multivariable regression. Results: Of 4, 362 30-day OHCA-survivors, 1, 051 were stroke-, AF-, ACS-, and HF-naïve and matched with controls using age, sex, and time of OHCA event. Absolute five-year risks for OHCA survivors vs. controls were for stroke: 6.3% [95% confidence interval (CI) 4.1–8.5] vs. 2.0% [1.6–2.5], AF: 7.9% [5.7–10.2] vs. 2.6% [2.1–3.1], ACS: 5.0% [3.2–6.8] vs. 1.5% [1.1–1.9], and HF: 12.7% [10.1–15.4] vs. 1.2% [0.9–1.6], respectively. Corresponding relative risks were 3.18 [95% CI 1.76–4.61] for stroke, 3.03 [1.93–4.14] for AF, 3.23 [1.69–4.77] for ACS, and 10.40 [6.57–14.13] for HF. Conclusion: When compared with population controls, OHCA survivors had significantly increased five-year risks of incident stroke, AF, ACS, and HF.