Ethics of ECPR research. (December 2021)

• Record Type: Journal Article
• Authors: Suverein, Martje M.; Shaw, David; Lorusso, Roberto; Delnoij, Thijs S.R.; Essers, Brigitte; Weerwind, Patrick W.; Townend, David; van de Poll, Marcel C.G.; Maessen, Jos G.
• Is Part Of: Resuscitation. Volume 169(2021)
• Page Start: 136
• Page End: 142
• Publication Date: 2021-12
• Subjects: Extracorporeal cardiopulmonary resuscitation -- Out-of-hospital cardiac arrest -- Refractory cardiac arrest -- Informed consent -- Ethical issues; ACLS Advanced Cardiac Life Support -- APACAR2 A Comparative Study Between a Pre-hospital and an In-hospital Circulatory Support Strategy (ECMO) in Refractory Cardiac Arrest -- BLS Basic Life Support -- CPR CardioPulmonary Resuscitation -- ECPB4OHCA Emergency Cardiopulmonary Bypass for Cardiac Arrest -- ECPR Extracorporeal CardioPulmonary Resuscitation -- ECLS Extracorporeal Life Support -- EFIC Exception from Informed Consent -- EMS Emergency Medical Services -- EROCA ECPR for Refractory Out-Of-Hospital Cardiac Arrest -- ICU Intensive Care Unit -- INCEPTION Early Initiation of Extracorporeal Life Support in Refractory OHCA -- IRB Institutional Review Board -- NCT ClinicalTrials.gov registry -- OCEBM Oxford Centre of Evidence‑Based Medicine -- OHCA Out-of-Hospital Cardiac Arrest -- PI Principal Investigator -- RCT Randomised Controlled Trial; Resuscitation -- Periodicals; Resuscitation -- Periodicals; Réanimation -- Périodiques; Electronic journals; 616.025
• DOI: 10.1016/j.resuscitation.2021.08.007
• Languages: English
• ISSNs: 0300-9572

Abstract

Abstract: The design of emergency medicine trials can raise several ethical concerns – risks may be greater, and randomisation may have to occur before consent. Research in emergency medicine is thus an illuminating context to explore the interplay between risk and randomisation, and the consequences for consent. Using a currently running trial, we describe possible concerns, considerations, and solutions to reconcile the conflicting interests of scientific inquiry, ethical principles, and clinical reality in emergency medicine research.