Eco-friendly copper nanomaterials-based dual-mode optical nanosensors for ultrasensitive trace determination of amoxicillin antibiotics residue in tap water samples. (March 2022)

• Record Type: Journal Article
• Authors: Anh, Nguyen Tuan; Dinh, Ngo Xuan; Van Tuan, Hoang; Doan, Mai Quan; Anh, Nguyen Ha; Khi, Nguyen Tien; Trang, Vu Thi; Tri, Doan Quang; Le, Anh-Tuan
• Is Part Of: Materials research bulletin. Volume 147(2022)
• Publication Date: 2022-03
• Subjects: Copper nanoparticles -- Cu-GO nanocomposites -- Amoxicillin -- Plasmonic colorimetric sensor -- Surface-enhanced Raman scattering sensor -- Dual-mode sensors; Materials -- Periodicals; Crystal growth -- Periodicals; Matériaux -- Périodiques; Cristaux -- Croissance -- Périodiques; Crystal growth; Materials; Periodicals; 620.11
• DOI: 10.1016/j.materresbull.2021.111649
• Languages: English
• ISSNs: 0025-5408

Abstract

Highlights: Copper nanoparticles (CuNPs) and copper/graphene oxide nanocomposites (Cu-GO) were synthesized by using a green electrochemical process. The CuNPs and Cu-GO nanocomposites were employed as a dual-mode colorimetric and surface enhanced Raman scattering (SERS) sensor for ultrahigh-sensitive detection of amoxicillin (AMX). The Cu and Cu-GO-based colorimetric sensors are suitable for on-site fast screening of AMX with the LOD values reached as low as 2.17 and 1.71 µM, respectively. For spectrophotometry sensors, the Cu and Cu-GO-coated SERS substrates showed ultralow-level AMX detection with the LODs ∼x223C 0.0152 and 0.0012 µM, respectively. The aggregation and electromagnetic/chemical mechanisms were used to interpret the AMX detection using optical nanosensors. Abstract: In this study, we have developed, for the first time, a colorimetric and surface-enhanced Raman scattering (SERS) dual-mode sensing platform for sensitive amoxicillin (AMX) detection by employing electrochemically-synthesized copper nanoparticles (CuNPs) and copper-graphene oxide (Cu-GO) nanocomposites with low cost and high purity. The obtained results revealed that Cu-GO-based colorimetric nanosensor exhibited high sensitivity with AMX antibiotics in a linear working range from 5 to 50 µM with a limit of detection (LOD) of 1.71 µM, which was 1.3 times lower than that of CuNPs-based colorimetric nanosensor (2.17 µM). More interestingly, Cu-GO-based SERS nanosensor has a linear range from 0.01 to 1000 µM and a LOD value ∼x223C 0.0012 µM, which was ∼x223C 13 times lower than CuNPs-based SERS sensor (0.0152 µM). Our developed dual-mode optical nanosensors also exhibited good practical applicability for AMX detection in real tap-water samples with high accuracy as recovery rates were calculated about 95% and RSDs were less than 5%. Graphical abstract: Image, graphical abstract