Metachronous breast cancer in a male with previous history of liposarcoma: A case report from Syria. (December 2021)

• Record Type: Journal Article
• Authors: Tarrab, Rand; Sabouni, Rami; Jarad, Lana; Mansour, Nour; Saifo, Maher S.
• Is Part Of: Annals of medicine and surgery. Volume 72(2021)
• Publication Date: 2021-12
• Subjects: Breast cancer -- Carcinoma -- Invasive ductal carcinoma -- Liposarcoma -- Male -- Metachronous -- Multiple primary cancers; Surgery -- Periodicals; Medicine -- Periodicals; General Surgery -- Periodicals; Education, Medical -- Periodicals; Periodicals; 617
• DOI: 10.1016/j.amsu.2021.103151
• Languages: English
• ISSNs: 2049-0801

Abstract

Abstract: Introduction: Multiple primary cancers (MPC) are defined as the occurrence of two or more non-related cancers. The acquiring of male breast cancer (MBC) as secondary cancer in a sequence of MPC is extremely rare. Only one case of breast cancer following liposarcoma (LP) was previously reported in a female patient. We report the first case of MBC following LP. Case presentation: A non-smoker male patient with a history of a well-differentiated liposarcoma was treated surgically and with radiotherapy 14 years ago with no signs of recurrence. The patient presented with a left breast mass; The excisional biopsy showed poorly differentiated grade III invasive ductal carcinoma. The patient underwent a mastectomy with axillary node resection and the final diagnosis was invasive ductal carcinoma stage IIA [T:2, N:0, M:0]. The tumor markers reported; Positive Estrogen Receptor (ER+), negative Progesterone Receptor (PR-), and negative Human Epidermal Receptor (HER-). He received eight sessions of chemotherapy with Docetaxel and 16 fractions of radiotherapy. The follow-up showed no signs of recurrence. Discussion: Despite the rarity of diagnosis MBC as a second primary. Studies have found a relation between different types of breast cancer in male patients, and further, a relation was also found between MBC and lymphoma. While no studies that link MBC and LP were previously reported. Conclusion: We found that acquiring a treated LP would not affect the MBC prognosis or its response to treatment, yet further studies are needed to confirm this outcome. Highlights: Multiple primary cancers occur in 2.4–17% of all people. The diagnosis of male breast cancer as a second primary is rare. Having male breast cancer following liposarcoma is even rarer. Well treated liposarcoma would not affect male breast cancer prognosis.