Development of Nickel Selenide@polydopamine Nanocomposites for Magnetic Resonance Imaging Guided NIR‐II Photothermal Therapy. Issue 23 (19th October 2021)

• Record Type: Journal Article
• Authors: Hu, Wenxue; Zhen, Wenyao; Zhang, Mengchao; Wang, Wei; Jia, Xiaodan; An, Shangjie; Wang, Yue; Guo, Zhuo; Jiang, Xiue
• Is Part Of: Advanced healthcare materials. Volume 10:Issue 23(2021)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2021-10-19
• Subjects: magnetic resonance imaging -- photothermal therapy -- polydopamine -- selenide nickel; Biomedical materials -- Periodicals; 610.28
• DOI: 10.1002/adhm.202101542
• Languages: English
• ISSNs: 2192-2640

Abstract

Abstract: The penetration depth of near‐infrared laser has greatly restricted the development of most photothermal agents. Recently, photothermal agents in the second near‐infrared (NIR‐II) window have drawn great attention as they can overcome above barrier. Herein, a novel "all in one" NIR‐II responsive nanoplatform (nickel selenide @polydopamine nanocomposites, NiSe@PDA NCs) based on in situ coating the polydopamine (PDA) on the surface of biomineralized nickel selenide nanoparticles (NiSe NPs) for dual‐model imaging‐guided photothermal therapy is reported. Under the illumination of NIR‐II laser (1064 nm), the photothermal conversion efficiency of NiSe@PDA NCs can reach 48.4%, which is higher than that of single NiSe NPs due to the enhanced molar extinction coefficient. In addition, because of the paramagnetic effect of NiSe NPs, the constructed NiSe@PDA NCs can be acted as T1 contrast agent for magnetic resonance imaging (MRI). Most importantly, the MRI contrast effect is enhanced with the coating of PDA layer due to the loose structure of PDA. Ultimately, both in vitro and in vivo experiments demonstrate that the developed NCs can achieve efficient MRI‐guided photothermal therapy for treating malignant tumor. Therefore, the designed NiSe@PDA NCs with excellent features show great potential for clinical MRI‐guided cancer therapy. Abstract : A novel "all in one" nickel selenide@polydopamine nanocomposites based on in situ coating of the polydopamine on the surface of biomineralized nickel selenide nanoparticles is developed as an attractive NIR‐II theranostic probe, which exhibits a high photothermal conversion efficiency of 48.4% and an efficient magnetic resonance imaging capability, and thus successfully achieves dual‐model imaging‐guided photothermal therapy.