Clinical Epidemiology of Hospitalized Patients With Coronavirus Disease 2019 (COVID-19) in Japan: Report of the COVID-19 Registry Japan. (28th September 2020)

• Record Type: Journal Article
• Authors: Matsunaga, Nobuaki; Hayakawa, Kayoko; Terada, Mari; Ohtsu, Hiroshi; Asai, Yusuke; Tsuzuki, Shinya; Suzuki, Setsuko; Toyoda, Ako; Suzuki, Kumiko; Endo, Mio; Fujii, Naoki; Suzuki, Michiyo; Saito, Sho; Uemura, Yukari; Shibata, Taro; Kondo, Masashi; Izumi, Kazuo; Terada-Hirashima, Junko; Mikami, Ayako; Sugiura, Wataru; Ohmagari, Norio
• Is Part Of: Clinical infectious diseases. Volume 73:Number 11(2021)
• Page Start: e3677
• Page End: e3689
• Publication Date: 2020-09-28
• Subjects: SARS-CoV-2 -- inpatients -- mortality -- epidemiology; Communicable diseases -- Periodicals; 616.905
• DOI: 10.1093/cid/ciaa1470
• Languages: English
• ISSNs: 1058-4838

Abstract

Abstract: Background: There is limited understanding of the characteristics of patients with coronavirus disease 2019 (COVID-19) requiring hospitalization in Japan. Methods: This study included 2638 cases enrolled from 227 healthcare facilities that participated in the COVID-19 Registry Japan (COVIREGI-JP). The inclusion criteria for enrollment of a case in COVIREGI-JP are both (1) a positive severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) test and (2) inpatient treatment at a healthcare facility. Results: The median age of hospitalized patients with COVID-19 was 56 years (interquartile range [IQR], 40–71 years). More than half of cases were male (58.9%, 1542/2619). Nearly 60% of the cases had close contact to confirmed or suspected cases of COVID-19. The median duration of symptoms before admission was 7 days (IQR, 4–10 days). The most common comorbidities were hypertension (15%, 396/2638) and diabetes without complications (14.2%, 374/2638). The number of nonsevere cases (68.2%, n = 1798) was twice the number of severe cases (31.8%, n = 840) at admission. The respiratory support during hospitalization includes those who received no oxygen support (61.6%, 1623/2636) followed by those who received supplemental oxygen (29.9%, 788/2636) and invasive mechanical ventilation/extracorporeal membrane oxygenation (8.5%, 225/2636). Overall, 66.9% (1762/2634) of patients were discharged home, while 7.5% (197/2634) died. Conclusions: We identified the clinical epidemiological features of COVID-19 in hospitalized patients in Japan. When compared with existing inpatient studies in other countries, these results demonstrated fewer comorbidities and a trend towards lower mortality. Abstract : Registry data of 2638 hospitalized COVID-19 cases revealed that mechanical ventilation was required in 8.5% of cases, and the overall mortality was 7.5%. Results of this study demonstrated fewer comorbidities and lower mortality than existing inpatient studies in other countries.