Hemagglutinin Nanoparticulate Vaccine with Controlled Photochemical Immunomodulation for Pathogenic Influenza‐Specific Immunity. Issue 23 (24th October 2021)

• Record Type: Journal Article
• Authors: Jeong, Hayoon; Lee, Chung‐Sung; Lee, Jangsu; Lee, Jonghwan; Hwang, Hee Sook; Lee, Min; Na, Kun
• Is Part Of: Advanced science. Volume 8:Issue 23(2021)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2021-10-24
• Subjects: influenza virus -- nanovaccine -- nasal antigen delivery -- nasal vaccine -- photochemical immunomodulation; Science -- Periodicals; 505
• DOI: 10.1002/advs.202100118
• Languages: English
• ISSNs: 2198-3844

Abstract

Abstract: Recently, viral infectious diseases, including COVID‐19 and Influenza, are the subjects of major concerns worldwide. One strategy for addressing these concerns focuses on nasal vaccines, which have great potential for achieving successful immunization via safe, easy, and affordable approaches. However, conventional nasal vaccines have major limitations resulting from fast removal when pass through nasal mucosa and mucociliary clearance hindering their effectiveness. Herein a nanoparticulate vaccine (NanoVac) exhibiting photochemical immunomodulation and constituting a new self‐assembled immunization system of a photoactivatable polymeric adjuvant with influenza virus hemagglutinin for efficient nasal delivery and antigen‐specific immunity against pathogenic influenza viruses is described. NanoVac increases the residence period of antigens and further enhances by spatiotemporal photochemical modulation in the nasal cavity. As a consequence, photochemical immunomodulation of NanoVacs successfully induces humoral and cellular immune responses followed by stimulation of mature dendritic cells, plasma cells, memory B cells, and CD4 + and CD8 + T cells, resulting in secretion of antigen‐specific immunoglobulins, cytokines, and CD8 + T cells. Notably, challenge with influenza virus after nasal immunization with NanoVacs demonstrates robust prevention of viral infection. Thus, this newly designed vaccine system can serve as a promising strategy for developing vaccines that are active against current hazardous pathogen outbreaks and pandemics. Abstract : A hemagglutinin nanoparticulate vaccine (NanoVac) exhibiting photochemical immunomodulation as a new immunization system is developed for efficient antigen‐specific immunity against pathogenic influenza viruses. The NanoVac increases the residence period of antigens by photochemical modulation effected with spatiotemporal light exposure. The NanoVac with controlled photochemical immunomodulation successfully induces humoral and cellular immune responses, resulting in robust prevention of viral infection.