Chemical Composition and Biological Screening of the Essential Oils of Micromeria macrosiphon and M. arganietorum (Lamiaceae). Issue 12 (16th November 2021)

• Record Type: Journal Article
• Authors: El Yaagoubi, Mohamed; Mechqoq, Hicham; Ortiz, Sergio; Cavaleiro, Carlos; Lecsö‐Bornet, Marylin; Pereira, Catarina Guerreiro; Rodrigues, Maria João; Custódio, Luísa; El Mousadik, Abdelhamid; Picot, Laurent; Kritsanida, Marina; Msanda, Fouad; El Aouad, Noureddine; Grougnet, Raphaël
• Is Part Of: Chemistry & biodiversity. Volume 18:Issue 12(2021)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2021-11-16
• Subjects: Micromeria macrosiphon -- M. arganietorum -- essential oil -- biological activities -- borneol; Biochemistry -- Periodicals; Molecular biology -- Periodicals; Biodiversity -- Periodicals; 572
• DOI: 10.1002/cbdv.202100653
• Languages: English
• ISSNs: 1612-1872

Abstract

Abstract: The chemical composition and in vitro biological activities of the essential oil (EO) of Micromeria macrosiphon Coss. and M. arganietorum (J. Emb.) R. Morales, two Lamiaceae endemic to south Morocco, were investigated. GC/MS analysis resulted in the identification of 36 metabolites from the EO of M. macrosiphon, 45 from M. arganietorum . Borneol was the major metabolite in both oils and together with related derivatives such as camphor, accounted for 2/3 of the EO of M. macrosiphon, 1/3 of those of M. arganietorum . Pinene and terpinene derivatives were also present in high proportions. From a chemotaxonomic point of view, the composition of the examined samples may be related to those of other species endemic to Macaronesia. Both EOs showed significant toxicity towards liver HepG2 and melanoma B16 4A5 tumor cell lines at 100 μg/mL; however, they were also cytotoxic towards S17 normal cell lines, with a selectivity index <1. No antibacterial activity was noticed against 52 strains at 100 μg/mL. Abstract :