ENIGMA‐anxiety working group: Rationale for and organization of large‐scale neuroimaging studies of anxiety disorders. Issue 1 (3rd July 2020)

• Record Type: Journal Article
• Authors: Bas‐Hoogendam, Janna Marie; Groenewold, Nynke A.; Aghajani, Moji; Freitag, Gabrielle F.; Harrewijn, Anita; Hilbert, Kevin; Jahanshad, Neda; Thomopoulos, Sophia I.; Thompson, Paul M.; Veltman, Dick J.; Winkler, Anderson M.; Lueken, Ulrike; Pine, Daniel S.; van der Wee, Nic J. A.; Stein, Dan J.
• Other Names: Agosta Federica investigator.; Åhs Fredrik investigator.; An Iseul investigator.; Alberton Bianca A. V. investigator.; Andreescu Carmen investigator.; Asami Takeshi investigator.; Assaf Michal investigator.; Avery Suzanne N. investigator.; Nicholas L. investigator.; Balderston investigator.; Barber Jacques P. investigator.; Battaglia Marco investigator.; Bayram Ali investigator.; Beesdo‐Baum Katja investigator.; Benedetti Francesco investigator.; Berta Rachel investigator.; Björkstrand Johannes investigator.; Blackford Jennifer Urbano investigator.; Blair James R. investigator.; Karina S. investigator.; Blair investigator.; Boehme Stephanie investigator.; Brambilla Paolo investigator.; Burkhouse Katie investigator.; Cano Marta investigator.; Canu Elisa investigator.; Cardinale Elise M. investigator.; Cardoner Narcis investigator.; Clauss Jacqueline A. investigator.; Cividini Camilla investigator.; Critchley Hugo D. investigator.; Udo investigator.; Dannlowski investigator.; Deckert Jurgen investigator.; Demiralp Tamer investigator.; Diefenbach Gretchen J. investigator.; Domschke Katharina investigator.; Doruyter Alex investigator.; Dresler Thomas investigator.; Erhardt Angelika investigator.; Fallgatter Andreas J. investigator.; Fañanás Lourdes investigator.; Brandee investigator.; Feola investigator.; Filippi Courtney A. investigator.; Filippi Massimo investigator.; Fonzo Gregory A. investigator.; Forbes Erika E. investigator.; Fox Nathan A. investigator.; Fredrikson Mats investigator.; Furmark Tomas investigator.; Ge Tian investigator.; Gerber Andrew J. investigator.; Gosnell Savannah N. investigator.; Grabe Hans J. investigator.; Grotegerd Dominik investigator.; Gur Raquel E. investigator.; Gur Ruben C. investigator.; Harmer Catherine J. investigator.; Harper Jennifer investigator.; Heeren Alexandre investigator.; Hettema John investigator.; Hofmann David investigator.; Hofmann Stefan G. investigator.; Jackowski Andrea P. investigator.; Andreas investigator.; Jansen investigator.; Kaczkurkin Antonia N. investigator.; Kingsley Ellen investigator.; Kircher Tilo investigator.; Kosti c Milutin investigator.; Kreifelts Benjamin investigator.; Krug Axel investigator.; Larsen Bart investigator.; Lee Sang‐Hyuk investigator.; Leehr Elisabeth J. investigator.; Leibenluft Ellen investigator.; Lochner Christine investigator.; Maggioni Eleonora investigator.; Makovac Elena investigator.; Mancini Matteo investigator.; Manfro Gisele G. investigator.; Månsson Kristoffer N. T. investigator.; Meeten Frances investigator.; Michałowski Jarosław investigator.; Milrod Barbara L. investigator.; Mühlberger Andreas investigator.; Lilianne R. investigator.; Mujica‐Parodi investigator.; Munjiza Ana investigator.; Mwangi Benson investigator.; Myers Michael investigator.; Igor Nenadi c investigator.; Neufang Susanne investigator.; Nielsen Jared A. investigator.; Oh Hyuntaek investigator.; Ottaviani Cristina investigator.; Pan Pedro M. investigator.; Pantazatos Spiro P. investigator.; Martin P. investigator.; Paulus investigator.; Perez‐Edgar Koraly investigator.; Peñate Wenceslao investigator.; Perino Michael T. investigator.; Peterburs Jutta investigator.; Pfleiderer Bettina investigator.; Phan K. Luan investigator.; Poletti Sara investigator.; Porta‐Casteràs Daniel investigator.; Price Rebecca B. investigator.; Pujol Jesus investigator.; Andrea investigator.; Reinecke investigator.; Rivero Francisco investigator.; Roelofs Karin investigator.; Rosso Isabelle investigator.; Saemann Philipp investigator.; Salas Ramiro investigator.; Salum Giovanni A. investigator.; Satterthwaite Theodore D. investigator.; Schneier Franklin investigator.; Schruers Koen R. J. investigator.; Schulz Stefan M. investigator.; Schwarzmeier Hanna investigator.; Seeger Fabian R. investigator.; Smoller Jordan W. investigator.; Soares Jair C. investigator.; Stark Rudolf investigator.; Stein Murray B. investigator.; Straube Benjamin investigator.; Straube Thomas investigator.; Strawn Jeffrey R. investigator.; Suarez‐Jimenez Benjamin investigator.; Boris investigator.; Suchan investigator.; Sylvester Chad M. investigator.; Talati Ardesheer investigator.; Tamburo Erica investigator.; Tükel Ras¸it investigator.; van den Heuvel Odile A. investigator.; Van der Auwera Sandra investigator.; van Nieuwenhuizen Helena investigator.; van Tol Marie‐José investigator.; van Velzen Laura S. investigator.; Bort Carlos Ventura investigator.; Vermeiren Robert R. J. M. investigator.; Visser Renee M. investigator.; Volman Inge investigator.; Wannemüller Andre investigator.; Wendt Julia investigator.; Werwath Kathryn E. investigator.; Westenberg P. Michiel investigator.; Wiemer Julian investigator.; Katharina investigator.; Wittfeld investigator.; Wu Mon‐Ju investigator.; Yang Yunbo investigator.; Zilverstand Anna investigator.; Zugman Andre investigator.; Zwiebel Hannah L. investigator.; Thompson P.M. guestEditor.; Jahanshad N. guestEditor.; Schmaal L. guestEditor.; Turner J.A. guestEditor.; Winkler A. guestEditor.; Thomopoulos S.I. guestEditor.; Egan G.F. guestEditor.; Kochunov P. guestEditor.;
• Is Part Of: Human brain mapping. Volume 43:Issue 1(2022)
• Page Start: 83
• Page End: 112
• Publication Date: 2020-07-03
• Subjects: amygdala -- anxiety disorders -- genetics -- limbic system -- magnetic resonance imaging -- neuroimaging -- prefrontal cortex; Brain mapping -- Periodicals; 611.81
• DOI: 10.1002/hbm.25100
• Languages: English
• ISSNs: 1065-9471

Abstract

Abstract: Anxiety disorders are highly prevalent and disabling but seem particularly tractable to investigation with translational neuroscience methodologies. Neuroimaging has informed our understanding of the neurobiology of anxiety disorders, but research has been limited by small sample sizes and low statistical power, as well as heterogenous imaging methodology. The ENIGMA‐Anxiety Working Group has brought together researchers from around the world, in a harmonized and coordinated effort to address these challenges and generate more robust and reproducible findings. This paper elaborates on the concepts and methods informing the work of the working group to date, and describes the initial approach of the four subgroups studying generalized anxiety disorder, panic disorder, social anxiety disorder, and specific phobia. At present, the ENIGMA‐Anxiety database contains information about more than 100 unique samples, from 16 countries and 59 institutes. Future directions include examining additional imaging modalities, integrating imaging and genetic data, and collaborating with other ENIGMA working groups. The ENIGMA consortium creates synergy at the intersection of global mental health and clinical neuroscience, and the ENIGMA‐Anxiety Working Group extends the promise of this approach to neuroimaging research on anxiety disorders. Abstract : Anxiety disorders are highly prevalent and disabling but seem particularly tractable to investigation with translational neuroscience methodologies. Neuroimaging has informed our understanding of the neurobiology of anxiety disorders, but research has been limited by small sample sizes and low statistical power, as well as heterogenous imaging methodology. The ENIGMA‐Anxiety Working Group has brought together researchers from around the world, in a harmonized and coordinated effort to address these challenges and generate more robust and reproducible findings. The ENIGMA consortium creates synergy at the intersection of global mental health and clinical neuroscience, and the ENIGMA‐Anxiety Working Group extends the promise of this approach to neuroimaging research on anxiety disorders.