Phytochemistry and anti‐inflammatory activity of iridoids from Dolichandrone spathacea collected in the mangrove forest of Phu Loc district, Thua Thien Hue province, Vietnam. Issue 6 (21st December 2021)

• Record Type: Journal Article
• Authors: Thao, Tran Thi Phuong; Chi, Nguyen Linh; Luu, Nguyen Thi; Dung, Nguyen Thi; Van Loc, Tran; Van Tuan, Nguyen; Hung, Trieu Quy; Nhung, Nguyen Thi Ai
• Is Part Of: Vietnam journal of chemistry. Volume 59:Issue 6(2021)
• Page Start: 943
• Page End: 950
• Publication Date: 2021-12-21
• Subjects: Dolichandrone spathacea -- mangrove forest -- iridoids -- triterpenoids -- anti‐inflammatory activity; Chemistry -- Periodicals; 540
• DOI: 10.1002/vjch.202100121
• Languages: English
• ISSNs: 0866-7144

Abstract

Abstract: From the leaves and barks of Dolichandrone spathacea collected in the mangrove forest of Hue province, three iridoids {6‐ O ‐[( E )‐4‐methoxy cinnamoyl]catalpol (1 ), 6‐ O ‐[( E )‐3, 4‐dimethoxy cinnamoyl]catalpol (2 ), nemoroside (3 )} and three ursane‐type triterpenoids [ursolic acid (4 ), pomolic acid (5 ), uncaric acid (6 )] were isolated and structurally elucidated. Besides, succrose octaacetate (7 ), daucosterol tetraacetate (8 ) and 1‐hentriacontanol (9 ) were identified from the fruits of this mangrove species. It is the first time compounds 6, 7, 9 were isolated from Dolichandrone spathacea . The main constituents of this plant, iridoids 1 and 2, were tested for the inhibition of IL‐6, TNF‐α factors and NO production. The anti‐inflammatory activity as well as the phytochemistry of the fruits of this species are reported for the first time.