Genotoxic stress of particulate matter in the electric furnace of an iron casting industry on human lung epithelial cells; an in vitro study. (2nd October 2021)

• Record Type: Journal Article
• Authors: Panjali, Zahra; Jafari-Tehrani, Behjat; Maghsoudi, Nader; Abdolmaleki, Parviz; Zendehdel, Rezvan
• Is Part Of: Toxin reviews. Volume 40:Number 4(2021)
• Page Start: 820
• Page End: 826
• Publication Date: 2021-10-02
• Subjects: Ferro-Ore -- particulate matter -- iron foundry -- A549 -- comet assay; Toxicology -- Periodicals; Toxins -- Periodicals; 615.905
• DOI: 10.1080/15569543.2020.1783318
• Languages: English
• ISSNs: 1556-9543

Abstract

Abstract: In foundries, various ores are used. Genotoxic assessment of ore-particles was the important aim of this study. In this regard, Ferrochromium, Ferrosilicon, Ferromanganese, and graphite were collected from an iron-casting industry. Also, the analysis has been performed by inductively coupled plasma optical emission spectroscopy (ICP-OES) and Fourier transform-infrared spectroscopy (FT-IR). The effective particle doses for A549-cells and genetic damages were evaluated using MTT and comet assay, respectively. The analysis indicated that, the samples contain Cr, Al, Cu, Fe, Mn, Zn, Ni, Pb, and SiO2 . Ferrosilicon was known as the highest toxic ore. Ore particles significantly induced DNA breaks ( p < 0.01) in a dose-dependent manner. A mixture of heavy-metals and silica in trace amounts caused genetic impairment. Moreover, the human health risk of the green–melting procedure is still notable in the casting industry.