Exposure to 4-methylimidazole as a food pollutant induces neurobehavioral toxicity in mother and developmental impairments in the offspring. (2nd October 2021)

• Record Type: Journal Article
• Authors: Mehri, Fereshteh; Salimi, Ahmad; Jamali, Zhaleh; Kahrizi, Farzad; Faizi, Mehrdad
• Is Part Of: Toxin reviews. Volume 40:Number 4(2021)
• Page Start: 1441
• Page End: 1446
• Publication Date: 2021-10-02
• Subjects: 4-methylimidazole -- developmental toxicity -- neurobehavioral toxicity -- abortion -- embryo-fetal toxicity; Toxicology -- Periodicals; Toxins -- Periodicals; 615.905
• DOI: 10.1080/15569543.2020.1728338
• Languages: English
• ISSNs: 1556-9543

Abstract

Abstract: 4-methylimidazole (4-MEI), is received to humans through the foods and other sources. We have investigated neurobehavioral and developmental toxicity of 4-MEI in mother and offspring in mice. Results in vivo, showed that 4-MEI (100, 200 and 300 mg/kg) can induce neurobehavioral toxicity in pregnant mice by abnormalities in the hippocampus and disrupt neurobehavioral functions. Observation on fetuses showed that 4-MEI induces abortion, decrease the weight and length of the fetus and pathological abnormalities. These results suggested 4-MEI induces neurobehavioral and developmental toxicity. It is hoped that these results will be helpful for awareness of humans which are exposed with 4-MEI.