Generation of tryptamine derivatives through biotransformation by Diaporthe sp. Issue 12 (2nd December 2021)

• Record Type: Journal Article
• Authors: Chen, Chao-Jun; Li, Dan; Yu, Kang-Ying; Zhou, Ming-Ming
• Is Part Of: Journal of Asian natural products research. Volume 23:Issue 12(2021)
• Page Start: 1164
• Page End: 1170
• Publication Date: 2021-12-02
• Subjects: Biotransformation -- Diaporthe sp. -- tryptamine -- cytotoxicity; Materia medica -- Asia -- Periodicals; Pharmacognosy -- Asia -- Periodicals; Medicinal plants -- Asia -- Periodicals; Medicine, Oriental -- Asia -- Periodicals; 615.321095
• DOI: 10.1080/10286020.2020.1866560
• Languages: English
• ISSNs: 1028-6020

Abstract

Abstract: Three new tryptamine derivatives diaporols T-V (1 –3 ) were isolated by adding tryptamine into the culture of Diaporthe sp., a fungus obtained from the leaves of Rhizophora stylosa . The structures of these compounds were elucidated by NMR spectroscopy and high resolution mass spectroscopic data. Among them, compound 1 showed moderate cytotoxic activity against SW480 cancer cell with IC50 9.84 μM. Graphical abstract: UF0001