One pair of new enantiomeric trinorsesquiterpenes from the aerial parts of Justicia gendarussa. Issue 12 (2nd December 2021)

• Record Type: Journal Article
• Authors: Zhang, Hai-Xin; Xia, Zhao; Xu, Tian-Qi; Xu, Wei; Chen, Yi-Min; Zhou, Guang-Xiong
• Is Part Of: Journal of Asian natural products research. Volume 23:Issue 12(2021)
• Page Start: 1140
• Page End: 1147
• Publication Date: 2021-12-02
• Subjects: Acanthaceae -- Justicia gendarussa -- X-ray diffraction -- ECD calculations -- enantiomers -- anti-inflammatory; Materia medica -- Asia -- Periodicals; Pharmacognosy -- Asia -- Periodicals; Medicinal plants -- Asia -- Periodicals; Medicine, Oriental -- Asia -- Periodicals; 615.321095
• DOI: 10.1080/10286020.2021.1871603
• Languages: English
• ISSNs: 1028-6020

Abstract

Abstract: A pair of new enantiomeric trinorsesquiterpenes, (+)-genpenterpene A (1a ) and (-)-genpenterpene A (1b ), together with seven known compounds (2 –8 ), were isolated from the aerial parts of Justicia gendarussa Burm.f.. All of these known compounds were isolated from this plant for the first time. Racemic genpenterpene A was separated by chiral HPLC column. Their chemical structures were elucidated based on extensive spectroscopic analysis, single crystal X-ray diffraction, and ECD calculations. (+)-genpenterpene A (1a ) exhibited potent inhibitory effect against nitric oxide production in lipopolysaccharide-activated RAW 264.7 mouse macrophage cells with an IC50 value of 9.54 ± 1.02 μM. Graphical abstract: UF0001