Biological and pharmacological activities of noscapine: Focusing on its receptors and mechanisms. (17th September 2021)

• Record Type: Journal Article
• Authors: Nourbakhsh, Fahimeh; Askari, Vahid Reza
• Is Part Of: BioFactors. Volume 47:Number 6(2021)
• Page Start: 975
• Page End: 991
• Publication Date: 2021-09-17
• Subjects: bradykinins -- cancer -- noscapine -- receptors -- microtubule targeting drugs -- therapeutics; Vitamins -- Physiological effect -- Periodicals; Trace elements -- Physiological effect -- Periodicals; Growth factors -- Physiological effect -- Periodicals; Plant growth promoting substances -- Physiological effect -- Periodicals; Biochemistry -- Periodicals; Nutritional Physiological Phenomena -- Periodicals; Trace Elements -- metabolism -- Periodicals; Vitamins -- metabolism -- Periodicals; Molecular Biology -- Periodicals; 612.399
• DOI: 10.1002/biof.1781
• Languages: English
• ISSNs: 0951-6433

Abstract

Abstract: Noscapine has been mentioned as one of the effective drugs with potential therapeutic applications. With few side effects and amazing capabilities, noscapine can be considered different from other opioids‐like structure compounds. Since 1930, extensive studies have been conducted in the field of pharmacological treatments from against malaria to control cough and cancer treatment. Furthermore, recent studies have shown that noscapine and some analogues, like 9‐bromonoscapine, amino noscapine, and 9‐nitronoscapine, can be used to treat polycystic ovaries syndrome, stroke, and other diseases. Given the numerous results presented in this field and the role of different receptors in the therapeutic effects of noscapine, we aimed to review the properties, therapeutic effects, and the role of receptors in the treatment of noscapine.