Computer‐Aided Living Polymerization Conducted under Continuous‐Flow Conditions†. Issue 2 (10th December 2021)

• Record Type: Journal Article
• Authors: Wang, Zeyu; Zhou, Yang; Chen, Mao
• Is Part Of: Chinese journal of chemistry. Volume 40:Issue 2(2022)
• Page Start: 285
• Page End: 296
• Publication Date: 2021-12-10
• Subjects: Polymers -- Synthetic methods -- Polymerization -- Flow chemistry -- Computer‐aided synthesis; Chemistry -- Periodicals; 540.5
• DOI: 10.1002/cjoc.202100544
• Languages: English
• ISSNs: 1001-604X

Abstract

Comprehensive Summary: Continuous‐flow techniques have promoted the development of synthetic chemistry due to advantages such as outstanding mass/heat transfer, on‐demand scalability, improved safety, precise regulation on reaction parameters, etc . Recently, the combination of flow polymerization with computer science has gained considerable interests, leading to a variety of cutting‐edge synthetic techniques. This review summarizes emerging achievements realized via the integration of computer science and living flow polymerizations, including 1) high‐throughput living polymerizations in flow, 2) programmable regulations of dispersity profile, sequence and topology for polymers, 3) modular design with online monitoring, as well as 4) self‐optimized living polymerizations in flow. We expect that this summary will furnish informative knowledge to scientists in related directions and inspire new ideas to further empower on‐demand polymer engineering with modern techniques. Abstract : In this review, new synthetic techniques and advantages brought by the integration of flow synthesis, computer science, and living polymerizations are discussed. We wish that this summary can provide informative knowledge to scientists in related directions and inspire new thoughts and ideas.