Decarbonylative cascade cyclization of ortho-cyanoarylacrylamides with pivaldehyde: Access to tert-butyl containing quinolone-2, 4(1H, 3H)-diones. (1st January 2022)

• Record Type: Journal Article
• Authors: Zhang, Cui; Xia, Wen-Jin; Fan, Tai-Gang; Ding, Xue-Ling; Li, Ya-Min
• Is Part Of: Tetrahedron. Volume 103(2022)
• Publication Date: 2022-01-01
• Subjects: Cascade cyclization -- Decarbonylation -- Pivaldehyde -- Quinolone-2, 4(1H, 3H)-diones -- Radical; Chemistry, Organic -- Periodicals; 547.005
• DOI: 10.1016/j.tet.2021.132547
• Languages: English
• ISSNs: 0040-4020

Abstract

Abstract: A TBPB initiated decarbonylative cascade cyclization of ortho -cyanoarylacrylamides with pivaldehyde leads to tert -butyl containing quinolone-2, 4(1 H, 3 H )-diones by formation of both C(sp 3 )–C(sp 3 ) and C(sp 3 )–C(sp 2 ) bonds. The reaction features simple reaction conditions and convenient reagents. Two radical additions are involved in the transformation. Graphical abstract: Image 1